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Tyrosyl DNA Phosphodiesterase 1 (TDP1)

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SCAN1; Tyr-DNA phosphodiesterase 1

Tyrosyl DNA Phosphodiesterase 1 (TDP1)
CCC C785
HGNC 18884
MGI 1920036
PubMed 20009512
RGD 1309618
UniProt Q9NUW8
Wiki TDP1
Tyrosyl-DNA phosphodiesterase 1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC785Hu01 Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tyrosyl DNA Phosphodiesterase 1 (TDP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tyrosyl DNA Phosphodiesterase 1 (TDP1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC785Hu ELISA Kit for Tyrosyl DNA Phosphodiesterase 1 (TDP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC785Mu01 Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC785Mu01 Polyclonal Antibody to Tyrosyl DNA Phosphodiesterase 1 (TDP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tyrosyl DNA Phosphodiesterase 1 (TDP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosyl DNA Phosphodiesterase 1 (TDP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC785Ra01 Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tyrosyl DNA Phosphodiesterase 1 (TDP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tyrosyl DNA Phosphodiesterase 1 (TDP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tyrosyl DNA Phosphodiesterase 1 (TDP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosyl DNA Phosphodiesterase 1 (TDP1) ELISA Kit Customized Service Offer
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  9. "Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages."J. Biol. Chem. 280:36518-36528(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Biochemical characterization of human Tyrosyl DNA Phosphodiesterase 2 (TDP2/TTRAP): a Mg2+/Mn2+-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes."J. Biol. Chem. 287:30842-30852(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures."J. Mol. Biol. 324:917-932(2002) [PubMed] [Europe PMC] [Abstract]
  16. "The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1."Structure 10:237-248(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of a transition state mimic for TDP1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide."Chem. Biol. 10:139-147(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes."J. Med. Chem. 47:829-837(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy."Nat. Genet. 32:267-272(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)."Nucleic Acids Res. 33:289-297(2005) [PubMed] [Europe PMC] [Abstract]
  21. "SCAN1 mutant Tdp1 accumulates the enzyme-DNA intermediate and causes camptothecin hypersensitivity."EMBO J. 24:2224-2233(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?"EMBO J. 26:4732-4743(2007) [PubMed] [Europe PMC] [Abstract]