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Tectorin Alpha (TECTa)

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TECT-A; DFNA12; DFNA8; DFNB21

Tectorin Alpha (TECTa)
CCC C787
HGNC 11720
MGI 109575
PubMed 12162770
RGD 1309824
UniProt O75443
Wiki TECTA
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane.
Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.The genomic coordinates used for the transcript record were based on transcript alignments and orthologous data.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectorin Alpha (TECTa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectorin Alpha (TECTa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectorin Alpha (TECTa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectorin Alpha (TECTa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectorin Alpha (TECTa) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectorin Alpha (TECTa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectorin Alpha (TECTa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectorin Alpha (TECTa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectorin Alpha (TECTa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectorin Alpha (TECTa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectorin Alpha (TECTa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectorin Alpha (TECTa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectorin Alpha (TECTa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectorin Alpha (TECTa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectorin Alpha (TECTa) ELISA Kit Customized Service Offer
  1. "Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment."Nat. Genet. 19:60-62(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)."Proc. Natl. Acad. Sci. U.S.A. 108:4218-4223(2011) [PubMed] [Europe PMC] [Abstract]
  4. "Mutation in the zonadhesin-like domain of alpha-tectorin associated with autosomal dominant non-syndromic hearing loss."Eur. J. Hum. Genet. 7:255-258(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Alpha-tectorin involvement in hearing disabilities: one gene -- two phenotypes."Hum. Genet. 105:211-216(1999) [PubMed] [Europe PMC] [Abstract]
  6. "An alpha-tectorin gene defect causes a newly identified autosomal recessive form of sensorineural pre-lingual non-syndromic deafness, DFNB21."Hum. Mol. Genet. 8:409-412(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A cysteine substitution in the zona pellucida domain of alpha-tectorin results in autosomal dominant, postlingual, progressive, mid frequency hearing loss in a Spanish family."J. Med. Genet. 38:E13-E13(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss."Arch. Otolaryngol. Head Neck Surg. 128:913-917(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Distinctive audiometric profile associated with DFNB21 alleles of TECTA."J. Med. Genet. 40:360-363(2003) [PubMed] [Europe PMC] [Abstract]
  10. "A genotype-phenotype correlation with gender-effect for hearing impairment caused by TECTA mutations."Cell. Physiol. Biochem. 14:369-376(2004) [PubMed] [Europe PMC] [Abstract]
  11. "A novel TECTA mutation in a Dutch DFNA8/12 family confirms genotype-phenotype correlation."J. Assoc. Res. Otolaryngol. 7:173-181(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Audioprofiling identifies TECTA and GJB2-related deafness segregating in a single extended pedigree."Clin. Genet. 72:130-137(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Two novel missense mutations in the TECTA gene in Korean families with autosomal dominant nonsyndromic hearing loss."Ann. Clin. Lab. Sci. 40:380-385(2010) [PubMed] [Europe PMC] [Abstract]
  15. "DFNA8/12 caused by TECTA mutations is the most identified subtype of nonsyndromic autosomal dominant hearing loss." Hum. Mutat. 32:825-834(2011) [PubMed] [Europe PMC] [Abstract]