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Tyrosine Kinase, Non Receptor 2 (TNK2)

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ACK; ACK1; Activated CDC42 Associated Kinase 1

Tyrosine Kinase, Non Receptor 2 (TNK2)
CCC C797
HGNC 19297
MGI 1858308
PubMed 18435854
RGD 1305957
UniProt Q07912
Wiki TNK2
Activated CDC42 kinase 1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain.
The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC797Hu01 Recombinant Tyrosine Kinase, Non Receptor 2 (TNK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC797Hu01 Polyclonal Antibody to Tyrosine Kinase, Non Receptor 2 (TNK2) WB; IHC; ICC; IP.
MAC797Hu22 Monoclonal Antibody to Tyrosine Kinase, Non Receptor 2 (TNK2) WB; IHC; ICC; IP.
Assay Kits SEC797Hu ELISA Kit for Tyrosine Kinase, Non Receptor 2 (TNK2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tyrosine Kinase, Non Receptor 2 (TNK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tyrosine Kinase, Non Receptor 2 (TNK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tyrosine Kinase, Non Receptor 2 (TNK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tyrosine Kinase, Non Receptor 2 (TNK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosine Kinase, Non Receptor 2 (TNK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tyrosine Kinase, Non Receptor 2 (TNK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tyrosine Kinase, Non Receptor 2 (TNK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tyrosine Kinase, Non Receptor 2 (TNK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tyrosine Kinase, Non Receptor 2 (TNK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosine Kinase, Non Receptor 2 (TNK2) ELISA Kit Customized Service Offer
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  5. "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas."Nat. Cell Biol. 1:507-513(1999) [PubMed] [Europe PMC] [Abstract]
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  7. "The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors."J. Biol. Chem. 276:18392-18398(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK."Biochem. Biophys. Res. Commun. 314:571-579(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox."Cancer Res. 65:10514-10523(2005) [PubMed] [Europe PMC] [Abstract]
  10. "SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1."FEBS Lett. 579:5040-5048(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase."J. Biol. Chem. 280:42219-42226(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1."Proc. Natl. Acad. Sci. U.S.A. 102:15901-15906(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
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  16. "Purification and enzyme activity of ACK1."Methods Enzymol. 406:250-260(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 104:8438-8443(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct."Biochem. Biophys. Res. Commun. 371:877-882(2008) [PubMed] [Europe PMC] [Abstract]
  19. "TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells."Breast Cancer Res. 10:R36-R36(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Dysregulation of Ack1 inhibits down-regulation of the EGF receptor."Exp. Cell Res. 314:1292-1300(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2."J. Biol. Chem. 284:8185-8194(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling."J. Biol. Chem. 284:34954-34963(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Regulation of Ack1 localization and activity by the amino-terminal SAM domain."BMC Biochem. 11:42-42(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases."Oncogene 29:3208-3216(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation."PLoS ONE 5:E9646-E9646(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity."Prostate 70:1274-1285(2010) [PubMed] [Europe PMC] [Abstract]
  30. "The Cdc42-associated kinase ACK1 is not auto-inhibited but requires Src for activation."Biochem. J. 435:355-364(2011) [PubMed] [Europe PMC] [Abstract]
  31. "Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin."Mol. Biol. Cell 22:493-502(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Shepherding AKT and androgen receptor by Ack1 tyrosine kinase."J. Cell. Physiol. 224:327-333(2010) [PubMed] [Europe PMC] [Abstract]
  33. "Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK."Nature 399:384-388(1999) [PubMed] [Europe PMC] [Abstract]
  34. "Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1."J. Biol. Chem. 279:44039-44045(2004) [PubMed] [Europe PMC] [Abstract]
  35. "Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors."Bioorg. Med. Chem. Lett. 18:6352-6356(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]