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Three Prime Repair Exonuclease 1 (TREX1)

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AGS1; ATRIP; DRN3; Aicardi-Goutieres Syndrome 1; 3'-5' exonuclease TREX1; DNase III

Three Prime Repair Exonuclease 1 (TREX1)
CCC C810
HGNC 12269
MGI 1925349
PubMed 20871604
UniProt Q9NSU2
Wiki TREX1
Three prime repair exonuclease 1 is the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, RVCL (Retinal Vasculopathy Cerebral Dystrophy), and Cree encephalitis.TREX1 bound to cytosolic HIV DNA and digested excess HIV DNA that would otherwise activate interferon expression via a pathway dependent on the kinase TBK1, the adaptor STING and the transcription factor IRF3. HIV-stimulated interferon production in cells deficient in TREX1 did not involve known nucleic acid sensors.


Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC810Hu01 Recombinant Three Prime Repair Exonuclease 1 (TREX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC810Hu01 Polyclonal Antibody to Three Prime Repair Exonuclease 1 (TREX1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Three Prime Repair Exonuclease 1 (TREX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Three Prime Repair Exonuclease 1 (TREX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Three Prime Repair Exonuclease 1 (TREX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Three Prime Repair Exonuclease 1 (TREX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Three Prime Repair Exonuclease 1 (TREX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Three Prime Repair Exonuclease 1 (TREX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Three Prime Repair Exonuclease 1 (TREX1) ELISA Kit Customized Service Offer
  1. "A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein."EMBO J. 18:3868-3875(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases."J. Biol. Chem. 274:19655-19660(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression of the TREX1 and TREX2 3'-->5' exonuclease genes."J. Biol. Chem. 276:14718-14727(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death."Mol. Cell 23:133-142(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease."Cell 131:873-886(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering."J. Biol. Chem. 282:10537-10543(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing."Immunity 39:482-495(2013) [PubMed] [Europe PMC] [Abstract]
  12. "The TREX1 C-terminal region controls cellular localization through ubiquitination."J. Biol. Chem. 288:28881-28892(2013) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus." Nat. Genet. 38:917-920(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome."Am. J. Hum. Genet. 80:811-815(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Clinical and molecular phenotype of Aicardi-Goutieres syndrome." Am. J. Hum. Genet. 81:713-725(2007) [PubMed] [Europe PMC] [Abstract]
  17. "A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus."J. Mol. Med. 85:531-537(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus." Nat. Genet. 39:1065-1067(2007) [PubMed] [Europe PMC] [Abstract]
  19. "C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy." Nat. Genet. 39:1068-1070(2007) [PubMed] [Europe PMC] [Abstract]
  20. "A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutieres syndrome."Am. J. Med. Genet. A 152:2612-2617(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutieres syndrome." Arthritis Rheum. 62:1469-1477(2010) [PubMed] [Europe PMC] [Abstract]