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Translin (TSN)

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BCLF1; REHF1; TRSLN; C3PO; Recombination Hotspot Associated Factor; Component 3 of promoter of RISC

Translin (TSN)
CCC C815
HGNC 12379
MGI 109263
PubMed 11126370
RGD 621107
UniProt Q15631
Wiki TSN_(gene
Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Translin (TSN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Translin (TSN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Translin (TSN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Translin (TSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Translin (TSN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Translin (TSN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Translin (TSN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Translin (TSN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Translin (TSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Translin (TSN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Translin (TSN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Translin (TSN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Translin (TSN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Translin (TSN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Translin (TSN) ELISA Kit Customized Service Offer
  1. "A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations."Nat. Genet. 10:167-174(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein."Genomics 43:237-241(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome."J. Biol. Chem. 272:11402-11407(1997) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA binding activity of Translin is mediated by a basic region in the ring-shaped structure conserved in evolution."FEBS Lett. 443:363-366(1999) [PubMed] [Europe PMC] [Abstract]
  8. "DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)."J. Cell Sci. 115:207-216(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of C3PO and mechanism of human RISC activation."Nat. Struct. Mol. Biol. 18:650-657(2011) [PubMed] [Europe PMC] [Abstract]