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Tyrosinase Related Protein 1 (TYRP1)

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CAS2; TYRP; TYRRP; CATB; GP75; TRP; b-PROTEIN; Catalase B; Glycoprotein 75; Melanoma antigen gp75; 5,6-dihydroxyindole-2-carboxylic acid oxidase

Tyrosinase Related Protein 1 (TYRP1)
CCC C819
HGNC 12450
MGI 98881
PubMed 11775055
RGD 1593266
UniProt P17643
Wiki TYRP1
Tyrp1 is a melanocyte-specific gene product involved in melanin synthesis. Mouse Tyrp1 possesses dihydroxyindole carboxylic acid oxidase activity, The function in human melanocytes is less clear. In addition to its role in melanin synthesis, Tyrp1 is involved in stabilizing of tyrosinase protein and modulating its catalytic activity.
Tyrp1 is also involved in maintenance of melanosome structure and affects melanocyte proliferation and melanocyte cell death.Mutations in the mouse Tyrp1 gene are associated with brown pelage, and in the human TYRP1 gene with oculocutaneous albinism type 3 (OCA3).The expression of TYRP1 is regulated by the Microphthalmia-associated transcription factor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tyrosinase Related Protein 1 (TYRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tyrosinase Related Protein 1 (TYRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tyrosinase Related Protein 1 (TYRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tyrosinase Related Protein 1 (TYRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosinase Related Protein 1 (TYRP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tyrosinase Related Protein 1 (TYRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tyrosinase Related Protein 1 (TYRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tyrosinase Related Protein 1 (TYRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tyrosinase Related Protein 1 (TYRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosinase Related Protein 1 (TYRP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tyrosinase Related Protein 1 (TYRP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tyrosinase Related Protein 1 (TYRP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tyrosinase Related Protein 1 (TYRP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tyrosinase Related Protein 1 (TYRP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosinase Related Protein 1 (TYRP1) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of the cDNA encoding human tyrosinase-related protein."Nucleic Acids Res. 18:2807-2807(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Mapping the human CAS2 gene, the homologue of the mouse brown (b) locus, to human chromosome 9p22-pter."Biochem. Biophys. Res. Commun. 178:227-235(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1."Mamm. Genome 9:50-53(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family."Genomics 29:24-34(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Downstream region of the human tyrosinase-related protein gene enhances its promoter activity."Biochem. Biophys. Res. Commun. 184:568-575(1992) [PubMed] [Europe PMC] [Abstract]
  7. "The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product."J. Exp. Med. 171:1375-1380(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Human tyrosinase-like protein (TYRL) carboxy terminus: closer homology with the mouse protein than previously reported."Nucleic Acids Res. 19:5803-5803(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity."Proc. Natl. Acad. Sci. U.S.A. 87:4809-4813(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Melanesian blond hair is caused by an amino acid change in TYRP1."Science 336:554-554(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Oculocutaneous albinism with TYRP1 gene mutations in a Caucasian patient."Pigment Cell Res. 19:239-242(2006) [PubMed] [Europe PMC] [Abstract]
  14. "DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics."Hum. Mutat. 34:827-835(2013) [PubMed] [Europe PMC] [Abstract]