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Tapasin (TPN)

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TAPBP; NGS17; TAPA; TPSN; TAP Associated Glycoprotein; TAP-binding protein

Tapasin (TPN)
CCC C820
HGNC 11566
MGI 1201689
PubMed 11274924
RGD 3819
UniProt O15533
Wiki Tapasin
Tapasin is a MHC class I antigen-processing molecule present in the lumen of the endoplasmic reticulum. It plays an important role in the maturation of MHC class I molecules in the ER lumen. Tapasin is one component of the peptide-loading complex, and can be found associated with MHC class I molecules after the MHC class I heavy chain has associated with Beta2 microglobulin.
The peptide-loading complex consists of TAP, tapasin, MHC class I, calreticulin, and ERp57. Tapasin recruits MHC class I molecules to the TAP peptide transporter, and also enhances loading of MHC class I with high-affinity peptides. Following loading of MHC class I with a high-affinity ligand, the interaction between tapasin and MHC class I disappears.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tapasin (TPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tapasin (TPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tapasin (TPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tapasin (TPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tapasin (TPN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tapasin (TPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tapasin (TPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tapasin (TPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tapasin (TPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tapasin (TPN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tapasin (TPN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tapasin (TPN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tapasin (TPN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tapasin (TPN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tapasin (TPN) ELISA Kit Customized Service Offer
  1. "Cloning and functional characterization of a subunit of the transporter associated with antigen processing."Proc. Natl. Acad. Sci. U.S.A. 94:8708-8713(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes."Science 277:1306-1309(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC."Eur. J. Immunol. 28:459-467(1998) [PubMed] [Europe PMC] [Abstract]
  4. "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC."J. Mol. Biol. 277:839-857(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Polymorphism of TAPASIN and its linkage disequilibria with HLA class II genes in the Japanese population."Tissue Antigens 52:279-281(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Granulocyte-macrophage colony-stimulating factor modulates tapasin expression in human neutrophils."J. Leukoc. Biol. 65:205-210(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA."Genes Immun. 5:101-108(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of an alternate splice form of tapasin in human melanoma."Hum. Immunol. 71:1018-1026(2010) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The N-terminal region of tapasin is required to stabilize the MHC class I loading complex."Eur. J. Immunol. 29:1858-1870(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Tapasin is required for efficient peptide binding to transporter associated with antigen processing."J. Biol. Chem. 275:1581-1586(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer."Immunity 30:21-32(2009) [PubMed] [Europe PMC] [Abstract]