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Thromboxane Receptor (TP)

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TBXA2R; TXA2-R; Thromboxane A2 Receptor; Prostanoid TP receptor

Thromboxane Receptor (TP)
CCC C822
HGNC 11608
MGI 98496
PubMed 14751539
RGD 3825
UniProt P21731
Wiki TP
The TP) is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G-protein coupled receptors coupled to the G protein Gq.The gene responsible for the thromboxane receptor, TBXA2R is found on chromosome 19 and spans 15 kilobases.
Thromboxane is a potent stimulator for platelet aggregation and clot formation and also plays a role in vascular tone. The thromboxane receptor is a member of the family of G protein-coupled receptors. Mutation of the receptor can lead to a bleeding disorder.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC822Hu01 Recombinant Thromboxane Receptor (TP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC822Hu01 Polyclonal Antibody to Thromboxane Receptor (TP) WB; IHC; ICC; IP.
MAC822Hu22 Monoclonal Antibody to Thromboxane Receptor (TP) WB; IHC; ICC; IP.
Assay Kits SEC822Hu ELISA Kit for Thromboxane Receptor (TP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thromboxane Receptor (TP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thromboxane Receptor (TP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thromboxane Receptor (TP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thromboxane Receptor (TP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thromboxane Receptor (TP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thromboxane Receptor (TP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thromboxane Receptor (TP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thromboxane Receptor (TP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thromboxane Receptor (TP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thromboxane Receptor (TP) ELISA Kit Customized Service Offer
  1. "Cloning and expression of cDNA for a human thromboxane A2 receptor."Nature 349:617-620(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and chromosomal mapping of the human thromboxane A2 receptor gene."J. Biol. Chem. 268:25253-25259(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor."J. Biol. Chem. 269:19256-19261(1994) [PubMed] [Europe PMC] [Abstract]
  4. ErratumJ. Biol. Chem. 270:7011-7011(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells."J. Pharmacol. Exp. Ther. 271:1034-1041(1994) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation."J. Clin. Invest. 97:949-956(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites."Mol. Pharmacol. 44:934-939(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes."Prostaglandins Other Lipid Mediat. 83:237-249(2007) [PubMed] [Europe PMC] [Abstract]
  11. "RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2)."Traffic 9:394-407(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor."Prostaglandins Other Lipid Mediat. 89:8-15(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder."J. Clin. Invest. 94:1662-1667(1994) [PubMed] [Europe PMC] [Abstract]