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Secretogranin V (SCG5)

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SCGV; P7B2; SGNE1; SgV; 7B2 Protein; Neuroendocrine protein 7B2; Prohormone Convertase Chaperone; Pituitary polypeptide; Secretory granule endocrine protein I

Secretogranin V (SCG5)
CCC C834
HGNC 10816
MGI 98289
PubMed 18439298
RGD 3669
UniProt P05408
Wiki SCG5
Neuroendocrine protein 7B2 is widely distributed in neuroendocrine tissues. It functions as a chaperone protein for the proprotein convertase PC2 and is required for the production of an active PC2 enzyme.
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC834Hu01 Recombinant Secretogranin V (SCG5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC834Hu01 Polyclonal Antibody to Secretogranin V (SCG5) WB; IHC; ICC; IP.
MAC834Hu22 Monoclonal Antibody to Secretogranin V (SCG5) WB; IHC; ICC; IP.
Assay Kits SEC834Hu ELISA Kit for Secretogranin V (SCG5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Secretogranin V (SCG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Secretogranin V (SCG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Secretogranin V (SCG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Secretogranin V (SCG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Secretogranin V (SCG5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Secretogranin V (SCG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Secretogranin V (SCG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Secretogranin V (SCG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Secretogranin V (SCG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Secretogranin V (SCG5) ELISA Kit Customized Service Offer
  1. "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2."FEBS Lett. 234:160-164(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man."Biochem. Biophys. Res. Commun. 174:156-162(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Structural organization of the gene encoding the neuroendocrine chaperone 7B2."Eur. J. Biochem. 236:60-67(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus."Arch. Biochem. Biophys. 225:525-534(1983) [PubMed] [Europe PMC] [Abstract]
  6. "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway."Cell 78:263-273(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Neuroendocrine secretory protein 7B2: structure, expression and functions."Biochem. J. 357:329-342(2001) [PubMed] [Europe PMC] [Abstract]