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Syntenin 1 (ST1)

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SDCBP; MDA9; SYCL; TACIP18; Syndecan Binding Protein; Scaffold protein Pbp1; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting 18

Syntenin 1 (ST1)
CCC C837
HGNC 10662
MGI 1337026
PubMed 21949238
RGD 621497
UniProt O00560
Wiki SDCBP
Syntenin-1 is a protein initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors.
The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC837Hu01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC837Hu01 Polyclonal Antibody to Syntenin 1 (ST1) WB,IHC
Assay Kits SEC837Hu ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Syntenin 1 (ST1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Syntenin 1 (ST1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Syntenin 1 (ST1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Syntenin 1 (ST1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syntenin 1 (ST1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Syntenin 1 (ST1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Syntenin 1 (ST1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Syntenin 1 (ST1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Syntenin 1 (ST1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syntenin 1 (ST1) ELISA Kit Customized Service Offer
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  2. "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains."Proc. Natl. Acad. Sci. U.S.A. 94:13683-13688(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene."Gene 207:105-110(1998) [PubMed] [Europe PMC] [Abstract]
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  7. , Submitted (FEB-2009) to UniProtKB
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  9. "A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface."Mol. Cell 3:423-433(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin."J. Biol. Chem. 275:19933-19941(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Schwannomin isoform-1 interacts with syntenin via PDZ domains."J. Biol. Chem. 276:33093-33100(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments."Mol. Biol. Cell 12:339-350(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein."Science 293:1136-1138(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "PDZ tandem of human syntenin: crystal structure and functional properties."Structure 11:459-468(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm."Structure 11:845-853(2003) [PubMed] [Europe PMC] [Abstract]
  21. "The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography."J. Mol. Biol. 338:483-493(2004) [PubMed] [Europe PMC] [Abstract]
  22. "The binding of the PDZ tandem of syntenin to target proteins."Biochemistry 45:3674-3683(2006) [PubMed] [Europe PMC] [Abstract]