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Spermine Synthase (SMS)

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SPMSY; Spermidine aminopropyltransferase

Spermine Synthase (SMS)
CCC C853
HGNC 11123
MGI 109490
PubMed 19859664
UniProt P52788
Wiki SMS
Spermine synthase (EC 2.5.1.22) is 1 of 4 enzymes involved in the synthesis of polyamines from arginine and methionine. The others are ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase , and spermidine synthase.Korhonen et al. (1995) isolated and sequenced cDNA clones encoding human spermine synthase.
The open reading frame encodes a 368-amino acid protein with little sequence similarity to proteins from bacterial and mammalian sources catalyzing almost identical reactions.In affected members of a family with Snyder-Robinson mental retardation syndrome (SRS) originally reported by Snyder and Robinson (1969), Cason et al. (2003) identified a splice site mutation in the SMS gene .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC853Hu01 Recombinant Spermine Synthase (SMS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC853Hu01 Polyclonal Antibody to Spermine Synthase (SMS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Spermine Synthase (SMS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermine Synthase (SMS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermine Synthase (SMS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermine Synthase (SMS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermine Synthase (SMS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermine Synthase (SMS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermine Synthase (SMS) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a cDNA encoding human spermine synthase."DNA Cell Biol. 14:841-847(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence analysis of 139 kb in Xp22.1 containing spermine synthase and the 5' region of PEX."Genomics 44:227-231(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. (In) Goldemberg S.H., Algranati I.D. (eds.);Proceedings of the international symposium on the biology and chemistry of polyamines, pp.91-98, ICSU Press, New York (1988)
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  8. "X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome."Eur. J. Hum. Genet. 11:937-944(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism."J. Biol. Chem. 283:16135-16146(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Targeted next generation sequencing as a diagnostic tool in epileptic disorders." Epilepsia 53:1387-1398(2012) [PubMed] [Europe PMC] [Abstract]
  14. "De novo loss-of-function mutations in SETD5, encoding a methyltransferase in a 3p25 microdeletion syndrome critical region, cause intellectual disability."Am. J. Hum. Genet. 94:618-624(2014) [PubMed] [Europe PMC] [Abstract]