≡

Snurportin 1 (SNUPN1)

[Edit]

SPN1; KPNBL; RNUT1; RNA, U Transporter 1

Snurportin 1 (SNUPN1)
CCC C863
HGNC 14245
MGI 1913319
PubMed 10209022
RGD 1303191
UniProt O95149
Wiki Snurportin
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain.
Snurportin-1 is a protein interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC863Hu01 Recombinant Snurportin 1 (SNUPN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC863Hu01 Polyclonal Antibody to Snurportin 1 (SNUPN1) WB; IHC
Assay Kits n/a CLIA Kit for Snurportin 1 (SNUPN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Snurportin 1 (SNUPN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC863Mu01 Recombinant Snurportin 1 (SNUPN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC863Mu01 Polyclonal Antibody to Snurportin 1 (SNUPN1) WB,IHC
Assay Kits n/a CLIA Kit for Snurportin 1 (SNUPN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Snurportin 1 (SNUPN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Snurportin 1 (SNUPN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Snurportin 1 (SNUPN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Snurportin 1 (SNUPN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Snurportin 1 (SNUPN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Snurportin 1 (SNUPN1) ELISA Kit Customized Service Offer
  1. "Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure."EMBO J. 17:4114-4126(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "CRM1-mediated recycling of snurportin 1 to the cytoplasm."J. Cell Biol. 145:255-264(1999) [PubMed] [Europe PMC] [Abstract]
  5. "SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta."Hum. Mol. Genet. 11:1785-1795(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Cross-talk between snurportin1 subdomains."Mol. Biol. Cell 16:4660-4671(2005) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1."EMBO J. 24:2235-2243(2005) [PubMed] [Europe PMC] [Abstract]