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Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1)

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SREBP1; Sterol Regulatory Element-Binding Protein 1

Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1)
CCC C868
HGNC 11289
MGI 107606
PubMed 23403193
RGD 69423
UniProt P36956
Wiki SREBF1
Sterol regulatory element-binding protein 1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC868Hu01 Recombinant Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC868Mu01 Recombinant Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC868Mu01 Polyclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) ELISA Kit Customized Service Offer
  1. "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene."Cell 75:187-197(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13."Genomics 25:667-673(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Alternative splicing produces a constitutively active form of human SREBP-1."Biochem. Biophys. Res. Commun. 368:820-826(2008) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane."J. Biol. Chem. 271:10379-10384(1996) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Co-crystal structure of sterol regulatory element binding protein 1a at 2.3-A resolution."Structure 6:661-672(1998) [PubMed] [Europe PMC] [Abstract]