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Signal Sequence Receptor Alpha (SSRa)

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SSR-A; SSR1; TRAPA; Translocon-Associated Protein Alpha

Signal Sequence Receptor Alpha (SSRa)
CCC C871
HGNC 11323
MGI 105082
PubMed 16135238
RGD 1310961
UniProt P43307
Wiki SSR1
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein.
is unusual in that it utilizes arrays of polyA signal sequences that are exclusively non-canonical.TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC871Hu01 Recombinant Signal Sequence Receptor Alpha (SSRa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC871Hu01 Polyclonal Antibody to Signal Sequence Receptor Alpha (SSRa) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Sequence Receptor Alpha (SSRa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Sequence Receptor Alpha (SSRa) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Sequence Receptor Alpha (SSRa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Sequence Receptor Alpha (SSRa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Sequence Receptor Alpha (SSRa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Sequence Receptor Alpha (SSRa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Sequence Receptor Alpha (SSRa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Signal Sequence Receptor Alpha (SSRa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Signal Sequence Receptor Alpha (SSRa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Signal Sequence Receptor Alpha (SSRa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Signal Sequence Receptor Alpha (SSRa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Sequence Receptor Alpha (SSRa) ELISA Kit Customized Service Offer
  1. "The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges."FEBS Lett. 349:324-326(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation."FEBS Lett. 455:223-227(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides."Nature 356:443-446(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Palmitoylated calnexin is a key component of the ribosome-translocon complex."EMBO J. 31:1823-1835(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]