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Signal Transducing Adaptor Molecule 2 (STAM2)

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Hbp; STAM2A; STAM2B; SH3 Domain And ITAM Motif; Hrs-binding protein

Signal Transducing Adaptor Molecule 2 (STAM2)
CCC C873
HGNC 11358
MGI 1929100
PubMed 16489693
RGD 1311497
UniProt O75886
Wiki STAM2
Signal transducing adapter molecule 2 is a protein closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation.
This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC873Hu01 Recombinant Signal Transducing Adaptor Molecule 2 (STAM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC873Hu01 Polyclonal Antibody to Signal Transducing Adaptor Molecule 2 (STAM2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Molecule 2 (STAM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Molecule 2 (STAM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC873Mu01 Recombinant Signal Transducing Adaptor Molecule 2 (STAM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC873Mu01 Polyclonal Antibody to Signal Transducing Adaptor Molecule 2 (STAM2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Molecule 2 (STAM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Molecule 2 (STAM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC873Ra01 Recombinant Signal Transducing Adaptor Molecule 2 (STAM2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC873Ra01 Polyclonal Antibody to Signal Transducing Adaptor Molecule 2 (STAM2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducing Adaptor Molecule 2 (STAM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducing Adaptor Molecule 2 (STAM2) ELISA Kit Customized Service Offer
  1. "STAM2, a new member of the STAM family, binding to the Janus kinases."FEBS Lett. 477:55-61(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes."J. Biol. Chem. 278:12513-12521(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain."Biochem. Biophys. Res. Commun. 331:929-937(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding."J. Biol. Chem. 280:628-636(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The solution structure of the VHS and SH3 domains of human signal transducing adaptor molecule 2."Submitted (NOV-2005) to the PDB data bank