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Selenophosphate Synthetase 1 (SEPHS1)

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SPS1; SPS; SELD; Selenide, water dikinase 1; Selenium donor protein 1

Selenophosphate Synthetase 1 (SEPHS1)
CCC C889
HGNC 19685
MGI 1923580
PubMed 16786570
RGD 1311182
UniProt P49903
Wiki SEPHS1
Selenide, water dikinase 1 is an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.
Synthesizes selenophosphate from selenide and ATP. ATP + selenide + H2O = AMP + selenophosphate + phosphate.
The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is proven, it is possible Cys-31 is the active site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Selenophosphate Synthetase 1 (SEPHS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Selenophosphate Synthetase 1 (SEPHS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Selenophosphate Synthetase 1 (SEPHS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Selenophosphate Synthetase 1 (SEPHS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selenophosphate Synthetase 1 (SEPHS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Selenophosphate Synthetase 1 (SEPHS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Selenophosphate Synthetase 1 (SEPHS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Selenophosphate Synthetase 1 (SEPHS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Selenophosphate Synthetase 1 (SEPHS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selenophosphate Synthetase 1 (SEPHS1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Selenophosphate Synthetase 1 (SEPHS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Selenophosphate Synthetase 1 (SEPHS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Selenophosphate Synthetase 1 (SEPHS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Selenophosphate Synthetase 1 (SEPHS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Selenophosphate Synthetase 1 (SEPHS1) ELISA Kit Customized Service Offer
  1. "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis."J. Biol. Chem. 270:21659-21664(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Human selenophosphate synthetase 1 has five splice variants with unique interactions, subcellular localizations and expression patterns."Biochem. Biophys. Res. Commun. 397:53-58(2010) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]