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Smoothened (SMO)

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Gx; SMOH

Smoothened (SMO)
CCC C891
HGNC 11119
MGI 108075
PubMed 23618354
RGD 3726
UniProt Q99835
Wiki Smoothened
Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine.Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation. SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex.SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and cancer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC891Hu01 Recombinant Smoothened (SMO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC891Hu01 Polyclonal Antibody to Smoothened (SMO) WB; IHC; ICC; IP.
Assay Kits SEC891Hu ELISA Kit for Smoothened (SMO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC891Mu01 Recombinant Smoothened (SMO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Smoothened (SMO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smoothened (SMO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Smoothened (SMO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Smoothened (SMO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Smoothened (SMO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Smoothened (SMO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smoothened (SMO) Polyclonal Antibody Customized Service Offer
Assay Kits SEC891Ra ELISA Kit for Smoothened (SMO) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog."Nature 384:129-134(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Activating Smoothened mutations in sporadic basal-cell carcinoma."Nature 391:90-92(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development."Curr. Biol. 19:1320-1326(2009) [PubMed] [Europe PMC] [Abstract]
  6. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened."PLoS Genet. 7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of the human smoothened receptor bound to an antitumour agent."Nature 497:338-343(2013) [PubMed] [Europe PMC] [Abstract]