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Sortilin 1 (SORT1)

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NT3; Gp95; NTR3; 100 kDa NT receptor; Glycoprotein 95; Neurotensin receptor 3

Sortilin 1 (SORT1)
CCC C895
HGNC 11186
MGI 1338015
PubMed 20816088
RGD 619999
UniProt Q99523
Wiki Sortilin_1
Sortilin is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC895Hu01 Recombinant Sortilin 1 (SORT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC895Hu01 Polyclonal Antibody to Sortilin 1 (SORT1) WB; IHC; ICC; IP.
MAC895Hu22 Monoclonal Antibody to Sortilin 1 (SORT1) WB; IHC; ICC; IP.
MAC895Hu21 Monoclonal Antibody to Sortilin 1 (SORT1) WB; IHC; ICC; IP.
Assay Kits SEC895Hu ELISA Kit for Sortilin 1 (SORT1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC895Hu CLIA Kit for Sortilin 1 (SORT1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPC895Mu61 Eukaryotic Sortilin 1 (SORT1) Positive Control; Immunogen; SDS-PAGE; WB.
APC895Mu61 Active Sortilin 1 (SORT1) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Sortilin 1 (SORT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sortilin 1 (SORT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC895Mu ELISA Kit for Sortilin 1 (SORT1) Enzyme-linked immunosorbent assay for Antigen Detection.
HEC895Mu High Sensitive ELISA Kit for Sortilin 1 (SORT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sortilin 1 (SORT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sortilin 1 (SORT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sortilin 1 (SORT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC895Ra ELISA Kit for Sortilin 1 (SORT1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  5. "The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor."J. Biol. Chem. 273:26273-26276(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding."EMBO J. 18:595-604(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin."FEBS Lett. 429:27-30(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase."J. Biol. Chem. 274:8832-8836(1999) [PubMed] [Europe PMC] [Abstract]
  9. "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein."EMBO J. 20:2180-2190(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains."J. Biol. Chem. 276:28541-28545(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line."Biochem. Biophys. Res. Commun. 298:760-764(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization."J. Cell. Physiol. 193:73-79(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1."Nature 415:937-941(2002) [PubMed] [Europe PMC] [Abstract]
  14. "The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin."EMBO J. 22:6430-6437(2003) [PubMed] [Europe PMC] [Abstract]
  15. ErratumEMBO J. 23:1680-1680(2004)
  16. "Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia."J. Neurosci. 23:1198-1205(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells."Int. J. Biochem. Cell Biol. 36:2153-2168(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Functional organization of the sortilin Vps10p domain."J. Biol. Chem. 279:50221-50229(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Sortilin is essential for proNGF-induced neuronal cell death."Nature 427:843-848(2004) [PubMed] [Europe PMC] [Abstract]
  20. "ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin."J. Neurosci. 25:5455-5463(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway."J. Neurosci. 25:6156-6166(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  24. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer."Cancer Res. 70:347-356(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Biological, clinical and population relevance of 95 loci for blood lipids." Nature 466:707-713(2010) [PubMed] [Europe PMC] [Abstract]
  28. "From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus." Nature 466:714-719(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling."Nat. Neurosci. 14:54-61(2011) [PubMed] [Europe PMC] [Abstract]
  31. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain."Nat. Struct. Mol. Biol. 16:96-98(2009) [PubMed] [Europe PMC] [Abstract]