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Damage Specific DNA Binding Protein 1 (DDB1)

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DDBA; UV-DDB1; XAP1; XPCE; XPE; XPE-BF; Xeroderma Pigmentosum,Complementation Group C; DDB p127 subunit; Damage-specific DNA-binding protein 1; HBV X-associated 1

Damage Specific DNA Binding Protein 1 (DDB1)
CCC C898
HGNC 2717
MGI 1202384
PubMed 16413485
RGD 621889
UniProt Q16531
Wiki DDB1
Damage-specific DNA binding protein 1, 127kDa, also known as DDB1, is the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit.
This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Damage Specific DNA Binding Protein 1 (DDB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Damage Specific DNA Binding Protein 1 (DDB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Damage Specific DNA Binding Protein 1 (DDB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Damage Specific DNA Binding Protein 1 (DDB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Damage Specific DNA Binding Protein 1 (DDB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Damage Specific DNA Binding Protein 1 (DDB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Damage Specific DNA Binding Protein 1 (DDB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Damage Specific DNA Binding Protein 1 (DDB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Damage Specific DNA Binding Protein 1 (DDB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Damage Specific DNA Binding Protein 1 (DDB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Damage Specific DNA Binding Protein 1 (DDB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Damage Specific DNA Binding Protein 1 (DDB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Damage Specific DNA Binding Protein 1 (DDB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Damage Specific DNA Binding Protein 1 (DDB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Damage Specific DNA Binding Protein 1 (DDB1) ELISA Kit Customized Service Offer
  1. "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein."Genomics 29:62-69(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein."J. Virol. 69:1107-1114(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells."Mutat. Res. 362:105-117(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity."Mol. Cell. Biol. 18:4391-4399(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Nuclear transport of human DDB protein induced by ultraviolet light."J. Biol. Chem. 275:21429-21434(2000) [PubMed] [Europe PMC] [Abstract]
  9. "UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation."J. Biol. Chem. 276:48175-48182(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Hepatitis B virus X protein interferes with cell viability through interaction with the p127-kDa UV-damaged DNA-binding protein."Virology 287:266-274(2001) [PubMed] [Europe PMC] [Abstract]
  11. "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage."Cell 113:357-367(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities."J. Virol. 77:6274-6283(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage."Nat. Cell Biol. 6:1003-1009(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase."Science 303:1371-1374(2004) [PubMed] [Europe PMC] [Abstract]
  15. "UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex."Cell 121:387-400(2005) [PubMed] [Europe PMC] [Abstract]
  16. "DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA."J. Biol. Chem. 280:39982-39989(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1."J. Virol. 79:13434-13441(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties."Mol. Cell. Biol. 25:9784-9792(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis."EMBO J. 25:1126-1136(2006) [PubMed] [Europe PMC] [Abstract]
  20. "DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases."Genes Dev. 20:2949-2954(2006) [PubMed] [Europe PMC] [Abstract]
  21. "An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage."J. Biol. Chem. 281:3753-3756(2006) [PubMed] [Europe PMC] [Abstract]
  22. "PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination."J. Biol. Chem. 281:6246-6252(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC."J. Biol. Chem. 281:13404-13411(2006) [PubMed] [Europe PMC] [Abstract]
  24. "Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage."Mol. Cell 22:383-394(2006) [PubMed] [Europe PMC] [Abstract]
  25. "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1."Mol. Cell 23:709-721(2006) [PubMed] [Europe PMC] [Abstract]
  26. "DDB1 maintains genome integrity through regulation of Cdt1."Mol. Cell. Biol. 26:7977-7990(2006) [PubMed] [Europe PMC] [Abstract]
  27. "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation."Nat. Cell Biol. 8:1277-1283(2006) [PubMed] [Europe PMC] [Abstract]
  28. "The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites."Proc. Natl. Acad. Sci. U.S.A. 103:2588-2593(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
  30. "The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A."Cancer Res. 68:5014-5022(2008) [PubMed] [Europe PMC] [Abstract]
  31. "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase."Genes Dev. 22:866-871(2008) [PubMed] [Europe PMC] [Abstract]
  32. "Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development."Mol. Cell. Biol. 28:5621-5633(2008) [PubMed] [Europe PMC] [Abstract]
  33. "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation."Oncogene 27:4056-4064(2008) [PubMed] [Europe PMC] [Abstract]
  34. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  35. "Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase."Nat. Cell Biol. 11:409-419(2009) [PubMed] [Europe PMC] [Abstract]
  36. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  37. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  38. "Orc2 protects ORCA from ubiquitin-mediated degradation."Cell Cycle 11:3578-3589(2012) [PubMed] [Europe PMC] [Abstract]
  39. "CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration."Mol. Cell 49:1147-1158(2013) [PubMed] [Europe PMC] [Abstract]
  40. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  41. "Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase."Cell 124:105-117(2006) [PubMed] [Europe PMC] [Abstract]
  42. "Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery."Nature 443:590-593(2006) [PubMed] [Europe PMC] [Abstract]
  43. "Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex."Cell 135:1213-1223(2008) [PubMed] [Europe PMC] [Abstract]
  44. "A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery."Nat. Struct. Mol. Biol. 17:105-111(2010) [PubMed] [Europe PMC] [Abstract]
  45. "The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation."Cell 147:1024-1039(2011) [PubMed] [Europe PMC] [Abstract]
  46. "Structure and function of WD40 domain proteins."Protein Cell 2:202-214(2011) [PubMed] [Europe PMC] [Abstract]
  47. "Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair."Proc. Natl. Acad. Sci. U.S.A. 109:E2737-E2746(2012) [PubMed] [Europe PMC] [Abstract]
  48. "Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide." Nature 512:49-53(2014) [PubMed] [Europe PMC] [Abstract]
  49. "Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs."Nat. Struct. Mol. Biol. 21:803-809(2014) [PubMed] [Europe PMC] [Abstract]