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Fibroblast Growth Factor 20 (FGF20)

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Fibroblast Growth Factor 20 (FGF20)
CCC C912
HGNC 3677
MGI 1891346
PubMed 16373575
RGD 71068
UniProt Q9NP95
Wiki FGF20
Fibroblast growth factor 20is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC912Hu01 Recombinant Fibroblast Growth Factor 20 (FGF20) Positive Control; Immunogen; SDS-PAGE; WB.
APC912Hu01 Active Fibroblast Growth Factor 20 (FGF20) Cell culture; Activity Assays.
Antibodies PAC912Hu01 Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20) WB; IHC; ICC; IP.
Assay Kits SEC912Hu ELISA Kit for Fibroblast Growth Factor 20 (FGF20) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor 20 (FGF20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20) Polyclonal Antibody Customized Service Offer
Assay Kits SEC912Mu ELISA Kit for Fibroblast Growth Factor 20 (FGF20) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor 20 (FGF20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibroblast Growth Factor 20 (FGF20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibroblast Growth Factor 20 (FGF20) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22."Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed] [Europe PMC] [Abstract]
  2. "FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain."Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis."Cancer Res. 61:3131-3138(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein."Am. J. Hum. Genet. 82:283-289(2008) [PubMed] [Europe PMC] [Abstract]
  7. "FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression." Mov. Disord. 24:455-459(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  9. "FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man."Dev. Cell 22:1191-1207(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix."Mol. Cell. Biol. 29:4663-4678(2009) [PubMed] [Europe PMC] [Abstract]