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Fibroblast Growth Factor 19 (FGF19)

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Fibroblast Growth Factor 19 (FGF19)
CCC C917
HGNC 3675
PubMed 21436455
RGD 620166
UniProt O95750
Wiki FGF19

FGF19 is a member of the fibroblast growth factor family. FGF19 was detected only in fetal but not adult brain tissue. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. Bile acids bind to the farnesoid X receptor, stimulating FGF19 transcription. Several FXR / bile acid response elements have been identified in the FGF19 gene. Human FGF19 transcripts have been shown to be stimulated approximately 300-fold by physiological concentrations of bile acids including chenodeoxycholic acid, glycochenodeoxycholic acid and obeticholic acid in explants of ileal mucosa. FGF19 regulates new bile acid synthesis, acting through the FGFR4/Klotho-β receptor complexes in the liver to inhibit CYP7A1. FGF19 has metabolic effects, affecting glucose and lipid metabolism when used in experimental mouse models.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC917Hu01 Recombinant Fibroblast Growth Factor 19 (FGF19) Positive Control; Immunogen; SDS-PAGE; WB.
APC917Hu01 Active Fibroblast Growth Factor 19 (FGF19) Cell culture; Activity Assays.
RPC917Hu02 Recombinant Fibroblast Growth Factor 19 (FGF19) Positive Control; Immunogen; SDS-PAGE; WB.
EPC917Hu61 Eukaryotic Fibroblast Growth Factor 19 (FGF19) Positive Control; Immunogen; SDS-PAGE; WB.
APC917Hu61 Active Fibroblast Growth Factor 19 (FGF19) Cell culture; Activity Assays.
Antibodies PAC917Hu01 Polyclonal Antibody to Fibroblast Growth Factor 19 (FGF19) WB; IHC
MAC917Hu21 Monoclonal Antibody to Fibroblast Growth Factor 19 (FGF19) WB; IHC; ICC; IP.
Assay Kits SCC917Hu CLIA Kit for Fibroblast Growth Factor 19 (FGF19) Chemiluminescent immunoassay for Antigen Detection.
SEC917Hu ELISA Kit for Fibroblast Growth Factor 19 (FGF19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibroblast Growth Factor 19 (FGF19) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibroblast Growth Factor 19 (FGF19) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibroblast Growth Factor 19 (FGF19) Polyclonal Antibody Customized Service Offer
Assay Kits SEC917Mu ELISA Kit for Fibroblast Growth Factor 19 (FGF19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPC917Ra21 OVA Conjugated Fibroblast Growth Factor 19 (FGF19) Immunogen; SDS-PAGE; WB.
Antibodies PAC917Ra08 Polyclonal Antibody to Fibroblast Growth Factor 19 (FGF19) WB; IHC; ICC; IP.
Assay Kits SEC917Ra ELISA Kit for Fibroblast Growth Factor 19 (FGF19) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain."Biochim. Biophys. Acta 1444:148-151(1999) [PubMed] [Europe PMC] [Abstract]
  2. "FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4."Cytokine 11:729-735(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis."Genes Dev. 17:1581-1591(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21."J. Biol. Chem. 282:26687-26695(2007) [PubMed] [Europe PMC] [Abstract]
  9. "C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors."J. Biol. Chem. 283:33304-33309(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression."Hepatology 49:297-305(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  12. "The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity."Biochemistry 43:629-640(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members." Mol. Cell. Biol. 27:3417-3428(2007) [PubMed] [Europe PMC] [Abstract]