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Gamma-Aminobutyric Acid B Receptor 1 (gABBR1)

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GABAB(1e); GABABR1; GABA-BR1; GABBR1-3; GPRC3A; HGB1a; Gamma-aminobutyric acid type B receptor subunit 1

Gamma-Aminobutyric Acid B Receptor 1 (gABBR1)
CCC C934
HGNC 4070
MGI 1860139
PubMed 15685626
RGD 621537
UniProt Q9UBS5
Wiki GABBR1
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals.
The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC934Hu01 Recombinant Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC934Hu01 Polyclonal Antibody to Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) WB; IHC; ICC; IP.
Assay Kits SEC934Hu ELISA Kit for Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) Recombinant Protein Customized Service Offer
Antibodies PAC934Mu01 Polyclonal Antibody to Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gamma-Aminobutyric Acid B Receptor 1 (gABBR1) ELISA Kit Customized Service Offer
  1. "Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels."Proc. Natl. Acad. Sci. U.S.A. 95:14991-14996(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Heterodimerization is required for the formation of a functional GABA(B) receptor."Nature 396:679-682(1998) [PubMed] [Europe PMC] [Abstract]
  3. "GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene."Biochem. Biophys. Res. Commun. 250:240-245(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization."Biol. Psychiatry 44:659-666(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy."Neurogenetics 2:47-54(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning of human GABABR1 and its tissue distribution."Brain Res. Mol. Brain Res. 64:137-140(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor."J. Biol. Chem. 275:32174-32181(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor."J. Pharmacol. Exp. Ther. 293:460-467(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Role of heteromer formation in GABAB receptor function."Science 283:74-77(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Marlin-1, a novel RNA-binding protein associates with GABA receptors."J. Biol. Chem. 279:13934-13943(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Subcellular distribution of GABA(B) receptor homo- and hetero-dimers."Biochem. J. 388:47-55(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor."J. Biol. Chem. 283:4665-4673(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2."Nat. Neurosci. 15:970-978(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Structural mechanism of ligand activation in human GABA(B) receptor."Nature 504:254-259(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy."Am. J. Med. Genet. 88:305-310(1999) [PubMed] [Europe PMC] [Abstract]