Corticotropin Releasing Hormone Receptor 1 (CRHR1)
[Edit]CRF-R; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f; Corticotropin-releasing factor receptor 1
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CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name. The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.
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Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma. CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC935Hu01 | Recombinant Corticotropin Releasing Hormone Receptor 1 (CRHR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC935Hu01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 1 (CRHR1) | WB; IHC; ICC; IP. |
MAC935Hu21 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 1 (CRHR1) | WB; IHC; ICC; IP. | |
Assay Kits | SEC935Hu | ELISA Kit for Corticotropin Releasing Hormone Receptor 1 (CRHR1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC935Mu01 | Recombinant Corticotropin Releasing Hormone Receptor 1 (CRHR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 1 (CRHR1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 1 (CRHR1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Corticotropin Releasing Hormone Receptor 1 (CRHR1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Corticotropin Releasing Hormone Receptor 1 (CRHR1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC935Ra01 | Recombinant Corticotropin Releasing Hormone Receptor 1 (CRHR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAC935Ra01 | Polyclonal Antibody to Corticotropin Releasing Hormone Receptor 1 (CRHR1) | WB; IHC; ICC; IP. |
MAC935Ra21 | Monoclonal Antibody to Corticotropin Releasing Hormone Receptor 1 (CRHR1) | WB; IHC; ICC; IP. | |
Assay Kits | SEC935Ra | ELISA Kit for Corticotropin Releasing Hormone Receptor 1 (CRHR1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
- "Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling."J. Biol. Chem. 288:15023-15034(2013) [PubMed] [Europe PMC] [Abstract]
- "Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1."J. Biol. Chem. 283:32900-32912(2008) [PubMed] [Europe PMC] [Abstract]
- "NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist."J. Biol. Chem. 285:38580-38589(2010) [PubMed] [Europe PMC] [Abstract]
- "Structure of class B GPCR corticotropin-releasing factor receptor 1."Nature 499:438-443(2013) [PubMed] [Europe PMC] [Abstract]