≡

Protease Activated Receptor 1 (PAR1)

[Edit]

FIIR; F2r; CF2R; HTR; PAR1; TR; Coagulation Factor II Receptor; Thrombin Receptor

Protease Activated Receptor 1 (PAR1)
CCC C939
HGNC 3537
MGI 101802
PubMed 15707890
RGD 2586
UniProt P25116
Wiki PAR1
Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, but also on endothelial cells, myocytes and neurons.There are 4 known protease-activated receptors or PARs, numbered from one to four.
Coagulation factor II (thrombin) receptor 1 is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. PAR1 is a G-protein coupled receptor.Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of heart disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC939Hu01 Recombinant Protease Activated Receptor 1 (PAR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC939Hu01 Polyclonal Antibody to Protease Activated Receptor 1 (PAR1) WB; IHC; ICC; IP.
MAC939Hu21 Monoclonal Antibody to Protease Activated Receptor 1 (PAR1) WB; IHC; ICC; IP.
Assay Kits SEC939Hu ELISA Kit for Protease Activated Receptor 1 (PAR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protease Activated Receptor 1 (PAR1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protease Activated Receptor 1 (PAR1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protease Activated Receptor 1 (PAR1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protease Activated Receptor 1 (PAR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protease Activated Receptor 1 (PAR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC939Ra01 Recombinant Protease Activated Receptor 1 (PAR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC939Ra01 Polyclonal Antibody to Protease Activated Receptor 1 (PAR1) WB; IHC; ICC; IP.
MAC939Ra21 Monoclonal Antibody to Protease Activated Receptor 1 (PAR1) WB; IHC; ICC; IP.
Assay Kits SEC939Ra ELISA Kit for Protease Activated Receptor 1 (PAR1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation."Cell 64:1057-1068(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization."J. Biol. Chem. 271:32874-32880(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin."J. Clin. Invest. 103:879-887(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis."J. Pharmacol. Exp. Ther. 328:378-389(2009) [PubMed] [Europe PMC] [Abstract]
  6. "The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression."FEBS Lett. 586:2351-2359(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  8. ErratumNat. Genet. 23:373-373(1999)
  9. "Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes."Biochemistry 33:3266-3279(1994) [PubMed] [Europe PMC] [Abstract]