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Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3)

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IP3-R; ITPR3; IP3R3; IP3 receptor isoform 3; Type 3 inositol 1,4,5-trisphosphate receptor

Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3)
CCC C943
HGNC 6182
MGI 96624
PubMed 20618519
RGD 2934
UniProt Q14573
Wiki ITPR3
The IP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. IP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life.
It is additionally the means for further IP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.Inositol 1,4,5-trisphosphate receptor, type 3 is a both a receptor for inositol triphosphate and a calcium channel.Expressed in intestinal crypt and villus epithelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC943Hu01 Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 3 (ITPR3) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors."Recept. Channels 2:9-22(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium."J. Biol. Chem. 269:1222-1230(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels."Proc. Natl. Acad. Sci. U.S.A. 99:7711-7716(2002) [PubMed] [Europe PMC] [Abstract]
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  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors."PLoS ONE 8:E69473-E69473(2013) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]