≡

Follicle Stimulating Hormone Receptor (FSHR)

[Edit]

FSHRO; LGR1; ODG1; FSH-Receptor; Follitropin receptor

Follicle Stimulating Hormone Receptor (FSHR)
CCC C947
HGNC 3969
MGI 95583
PubMed 19017414
RGD 2632
UniProt P23945
Wiki FSH-receptor
The follicle stimulating hormone receptor is a transmembrane receptor that interacts with the follicle stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning of FSH. FSHRs are found in the ovary, testis, and uterus.The FSHR consists of 695 amino acids and has a molecular mass of about 76 kDa. Like other GPCRs, the FSH-receptor possess seven membrane-spanning domains or transmembrane helices.Upon binding FSH externally to the membrane, a transduction of the signal takes place that activates the G protein that is bound to the receptor internally. With FSH attached, the receptor shifts conformation and thus mechanically activates the G protein, which detaches from the receptor and activates the cAMP system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC947Hu01 Recombinant Follicle Stimulating Hormone Receptor (FSHR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC947Hu01 Polyclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR) WB; IHC; ICC; IP.
MAC947Hu22 Monoclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR) WB; IHC; ICC; IP.
LAC947Hu71 Biotin-Linked Polyclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR) WB; IHC; ICC.
Assay Kits SEC947Hu ELISA Kit for Follicle Stimulating Hormone Receptor (FSHR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Follicle Stimulating Hormone Receptor (FSHR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Follicle Stimulating Hormone Receptor (FSHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Follicle Stimulating Hormone Receptor (FSHR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Follicle Stimulating Hormone Receptor (FSHR) Recombinant Protein Customized Service Offer
Antibodies PAC947Ra01 Polyclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Follicle Stimulating Hormone Receptor (FSHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Follicle Stimulating Hormone Receptor (FSHR) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Follicle Stimulating Hormone Receptor (FSHR) Recombinant Protein Customized Service Offer
Antibodies PAC947Ov01 Polyclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Follicle Stimulating Hormone Receptor (FSHR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Follicle Stimulating Hormone Receptor (FSHR) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of human FSH receptor cDNA."Biochem. Biophys. Res. Commun. 175:1125-1130(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts."Endocrinology 131:799-806(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells."Mol. Cell. Endocrinol. 89:141-151(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor."Biochem. Biophys. Res. Commun. 188:1077-1083(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene."Mol. Cell. Endocrinol. 102:93-102(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10."J. Mol. Endocrinol. 12:265-271(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Alternatively spliced variants of the follicle-stimulating hormone receptor gene in the testis of infertile men."Fertil. Steril. 77:499-504(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions."Structure 3:1341-1353(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of human follicle-stimulating hormone in complex with its receptor."Nature 433:269-277(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure."Cell 82:959-968(1995) [PubMed] [Europe PMC] [Abstract]
  14. "A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors."J. Clin. Endocrinol. Metab. 82:1020-1026(1997) [PubMed] [Europe PMC] [Abstract]
  15. "An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man."J. Clin. Endocrinol. Metab. 81:1367-1370(1996) [PubMed] [Europe PMC] [Abstract]
  16. "The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry."J. Clin. Endocrinol. Metab. 83:4338-4343(1998) [PubMed] [Europe PMC] [Abstract]
  17. "A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor."J. Clin. Invest. 102:1352-1359(1998) [PubMed] [Europe PMC] [Abstract]
  18. "New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype."Mol. Endocrinol. 13:1844-1854(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  20. ErratumNat. Genet. 23:373-373(1999)
  21. "Distribution and function of FSH receptor genetic variants in normal men."Andrologia 34:172-176(2002) [PubMed] [Europe PMC] [Abstract]
  22. "A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure."J. Clin. Endocrinol. Metab. 87:1151-1155(2002) [PubMed] [Europe PMC] [Abstract]
  23. "A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics."Hum. Reprod. 18:251-256(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies."J. Clin. Endocrinol. Metab. 88:3491-3498(2003) [PubMed] [Europe PMC] [Abstract]
  25. "A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome."N. Engl. J. Med. 349:753-759(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor."N. Engl. J. Med. 349:760-766(2003) [PubMed] [Europe PMC] [Abstract]
  27. "A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome."J. Clin. Endocrinol. Metab. 89:1255-1258(2004) [PubMed] [Europe PMC] [Abstract]
  28. "Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology."J. Clin. Endocrinol. Metab. 91:555-562(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome."Hum. Mutat. 29:91-98(2008) [PubMed] [Europe PMC] [Abstract]