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Free Fatty Acid Receptor 2 (FFAR2)

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FFA2R; GPR43; FFA2; GPCR43; G-protein coupled receptor 43

Free Fatty Acid Receptor 2 (FFAR2)
CCC C949
HGNC 4501
MGI 2441731
PubMed 20837008
RGD 1359614
UniProt O15552
Wiki FFAR2
The physiologic responses to galanin (GAL) are mediated through specific membrane receptors called GALRs, which are members of the G protein-coupled receptor (GPCR) family. One product contained a segment showing 100% homology to a portion of the 3-prime region of the human CD22 gene . The authors identified a PAC clone in the sequence databases that overlaps this region and contains a novel putative GPCR gene, GPR43.
The intronless GPR43 gene is located approximately 77 kb downstream of the GPR42 gene . GPR43 encodes a deduced 330-amino acid protein with 7 transmembrane domains. The GPR43 protein shares 28% amino acid identity with GPR40and little similarity with GALRs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Free Fatty Acid Receptor 2 (FFAR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Free Fatty Acid Receptor 2 (FFAR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Free Fatty Acid Receptor 2 (FFAR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Free Fatty Acid Receptor 2 (FFAR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Free Fatty Acid Receptor 2 (FFAR2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC949Mu01 Recombinant Free Fatty Acid Receptor 2 (FFAR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPC949Mu02 Recombinant Free Fatty Acid Receptor 2 (FFAR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC949Mu01 Polyclonal Antibody to Free Fatty Acid Receptor 2 (FFAR2) WB; IHC; ICC; IP.
PAC949Mu02 Polyclonal Antibody to Free Fatty Acid Receptor 2 (FFAR2) WB; IHC; ICC; IP.
Assay Kits SEC949Mu ELISA Kit for Free Fatty Acid Receptor 2 (FFAR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC949Ra01 Recombinant Free Fatty Acid Receptor 2 (FFAR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPC949Ra02 Recombinant Free Fatty Acid Receptor 2 (FFAR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Free Fatty Acid Receptor 2 (FFAR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Free Fatty Acid Receptor 2 (FFAR2) Polyclonal Antibody Customized Service Offer
Assay Kits SEC949Ra ELISA Kit for Free Fatty Acid Receptor 2 (FFAR2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids."Biochem. Biophys. Res. Commun. 303:1047-1052(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids." J. Biol. Chem. 278:11312-11319(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation."J. Biol. Chem. 278:25481-25489(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids."J. Biol. Chem. 283:32913-32924(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Allosteric rescuing of loss-of-function FFAR2 mutations."FEBS Lett. 584:4208-4214(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense."J. Immunol. 185:6899-6910(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Mutational analysis of G-protein coupled receptor--FFA2."Biochem. Biophys. Res. Commun. 405:122-127(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3."J. Biol. Chem. 287:41195-41209(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor."J. Biol. Chem. 288:17296-17312(2013) [PubMed] [Europe PMC] [Abstract]