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Caveolin 2 (CAV2)

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Caveolin 2 (CAV2)
CCC C952
HGNC 1528
MGI 107571
PubMed 11884617
RGD 620348
UniProt P51636
Wiki Caveolin_2
Caveolin-2 is a protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis.
This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC952Hu01 Recombinant Caveolin 2 (CAV2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC952Hu01 Polyclonal Antibody to Caveolin 2 (CAV2) WB; IHC; ICC; IP.
MAC952Hu22 Monoclonal Antibody to Caveolin 2 (CAV2) WB; IHC; ICC; IP.
Assay Kits SEC952Hu ELISA Kit for Caveolin 2 (CAV2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caveolin 2 (CAV2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caveolin 2 (CAV2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caveolin 2 (CAV2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caveolin 2 (CAV2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caveolin 2 (CAV2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caveolin 2 (CAV2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caveolin 2 (CAV2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caveolin 2 (CAV2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caveolin 2 (CAV2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caveolin 2 (CAV2) ELISA Kit Customized Service Offer
  1. "Identification, sequence, and expression of caveolin-2 defines a caveolin gene family."Proc. Natl. Acad. Sci. U.S.A. 93:131-135(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo."J. Biol. Chem. 272:29337-29346(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."FEBS Lett. 448:221-230(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes."FEBS Lett. 434:127-134(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1."J. Biol. Chem. 277:34556-34567(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27)."Biochemistry 43:13694-13706(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells."Biochemistry 47:101-111(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]