Amyloid Beta Precursor Protein Binding Protein B3 (APBB3)

Amyloid beta A4 precursor protein-binding family B member 3 is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.

Like Fe65 and Fe65L1, the rat Fe65L2 protein contains 2 phosphotyrosine-binding (PTB) domains and a WW domain. Northern blot analysis detected predominant expression of a 2-kb Fe65L2 mRNA in rat brain and testis.Fe65L2 encodes a deduced 486-amino acid protein that shares 86% sequence identity with the rat protein.