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Cathepsin B (CTSB)

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CTS-B; APPS; CPSB; APP secretase

Cathepsin B (CTSB)
CCC C964
HGNC 2527
MGI 88561
PubMed 14587299
RGD 621509
UniProt P07858
Wiki Cathepsin_B
Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. The protein is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of β-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade β-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC964Hu01 Recombinant Cathepsin B (CTSB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC964Hu01 Polyclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
MAC964Hu22 Monoclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
MAC964Hu21 Monoclonal Antibody to Cathepsin B (CTSB) WB
MAC964Hu24 Monoclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
MAC964Hu25 Monoclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
MAC964Hu23 Monoclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
Assay Kits SEC964Hu ELISA Kit for Cathepsin B (CTSB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC964Mu01 Recombinant Cathepsin B (CTSB) Positive Control; Immunogen; SDS-PAGE; WB.
RPC964Mu02 Recombinant Cathepsin B (CTSB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC964Mu01 Polyclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
PAC964Mu02 Polyclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
Assay Kits SEC964Mu ELISA Kit for Cathepsin B (CTSB) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC964Ra01 Recombinant Cathepsin B (CTSB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC964Ra01 Polyclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
MAC964Ra21 Monoclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
MAC964Ra22 Monoclonal Antibody to Cathepsin B (CTSB) WB; IHC; ICC; IP.
Assay Kits SEC964Ra ELISA Kit for Cathepsin B (CTSB) Enzyme-linked immunosorbent assay for Antigen Detection.
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  14. "The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity."EMBO J. 10:2321-2330(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structures of human procathepsin B at 3.2- and 3.3-A resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide."FEBS Lett. 384:211-214(1996) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of the wild-type human procathepsin B at 2.5-A resolution reveals the native active site of a papain-like cysteine protease zymogen."J. Mol. Biol. 271:774-788(1997) [PubMed] [Europe PMC] [Abstract]