≡

Cathepsin H (CTSH)

[Edit]

CTS-H; CPSB; ACC4; ACC5; Minichain; Pro-cathepsin H

Cathepsin H (CTSH)
CCC C966
HGNC 2535
MGI 107285
PubMed 14515996
RGD 2447
UniProt P09668
Wiki Cathepsin_H
Cathepsin H is is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor.
The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors.Two transcript variants encoding different isoforms have been found for this gene.One form of Batten disease, representing perhaps about one-fourth of all cases, has been found to show deficiency of cathepsin H. The Batten disease phenotype maps to chromosome 16, however.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC966Hu01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC966Hu01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
Assay Kits SEC966Hu ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC966Mu01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC966Mu01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cathepsin H (CTSH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cathepsin H (CTSH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC966Ra01 Recombinant Cathepsin H (CTSH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC966Ra01 Polyclonal Antibody to Cathepsin H (CTSH) WB; IHC; ICC; IP.
Assay Kits SEC966Ra ELISA Kit for Cathepsin H (CTSH) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase."Nucleic Acids Res. 17:9471-9471(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of a truncated form of cathepsin H in human prostate tumor cells."J. Biol. Chem. 277:11533-11538(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H."Biol. Chem. Hoppe-Seyler 369:469-475(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Amino acid sequences of the human kidney cathepsins H and L."FEBS Lett. 228:341-345(1988) [PubMed] [Europe PMC] [Abstract]
  8. "Human cathepsins B, H and L: characterization by amino acid sequences and some kinetics of inhibition by the kininogens."(In) Turk V. (eds.);Cysteine proteinases and their inhibitors, pp.3-18, Walter de Gruyter, Berlin and New York (1986)
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]