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Microtubule Associated Protein 7 (MAP7)

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E-MAP-115; EMAP115; Ensconsin; Epithelial microtubule-associated protein of 115 kDa

Microtubule Associated Protein 7 (MAP7)
CCC C974
HGNC 6869
MGI 1328328
PubMed 24687279
RGD 1308866
UniProt Q14244
Wiki MAP7
Ensconsin is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation.
This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins APC974Hu01 Active Microtubule Associated Protein 7 (MAP7) Cell culture; Activity Assays.
EPC974Hu61 Eukaryotic Microtubule Associated Protein 7 (MAP7) Positive Control; Immunogen; SDS-PAGE; WB.
APC974Hu61 Active Microtubule Associated Protein 7 (MAP7) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein 7 (MAP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein 7 (MAP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein 7 (MAP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein 7 (MAP7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Microtubule Associated Protein 7 (MAP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein 7 (MAP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein 7 (MAP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein 7 (MAP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein 7 (MAP7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPC974Ra61 Eukaryotic Microtubule Associated Protein 7 (MAP7) Positive Control; Immunogen; SDS-PAGE; WB.
APC974Ra61 Active Microtubule Associated Protein 7 (MAP7) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Microtubule Associated Protein 7 (MAP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Microtubule Associated Protein 7 (MAP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Microtubule Associated Protein 7 (MAP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Microtubule Associated Protein 7 (MAP7) ELISA Kit Customized Service Offer
  1. "Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells."J. Cell Biol. 123:357-371(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation."J. Cell Biol. 131:1015-1024(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts."J. Invest. Dermatol. 112:216-225(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Rapid dynamics of the microtubule binding of ensconsin in vivo."J. Cell Sci. 114:3885-3897(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]