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Glutathione Peroxidase 2, Gastrointestinal (GPX2)

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GI-GPx; GPRP; GSHPX-GI; GSHPx-2; Gastrointestinal glutathione peroxidase; Glutathione peroxidase-gastrointestinal; Glutathione peroxidase-related protein 2

Glutathione Peroxidase 2, Gastrointestinal (GPX2)
CCC C993
HGNC 4554
MGI 106609
PubMed 15795427
RGD 727780
UniProt P18283
Wiki GPX2_(gene
GPX2 is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract.
The antioxidant enzyme glutathione peroxidase 2 is one out of eight known glutathione peroxidases in humans. Mammalian Gpx1, GPx2, Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC993Hu01 Recombinant Glutathione Peroxidase 2, Gastrointestinal (GPX2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC993Hu01 Polyclonal Antibody to Glutathione Peroxidase 2, Gastrointestinal (GPX2) WB; IHC; ICC; IP.
MAC993Hu21 Monoclonal Antibody to Glutathione Peroxidase 2, Gastrointestinal (GPX2) WB; IHC; ICC; IP.
Assay Kits SEC993Hu ELISA Kit for Glutathione Peroxidase 2, Gastrointestinal (GPX2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutathione Peroxidase 2, Gastrointestinal (GPX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutathione Peroxidase 2, Gastrointestinal (GPX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutathione Peroxidase 2, Gastrointestinal (GPX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutathione Peroxidase 2, Gastrointestinal (GPX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione Peroxidase 2, Gastrointestinal (GPX2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glutathione Peroxidase 2, Gastrointestinal (GPX2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glutathione Peroxidase 2, Gastrointestinal (GPX2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glutathione Peroxidase 2, Gastrointestinal (GPX2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glutathione Peroxidase 2, Gastrointestinal (GPX2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione Peroxidase 2, Gastrointestinal (GPX2) ELISA Kit Customized Service Offer
  1. "A human cDNA sequence of a novel glutathione peroxidase-related protein."Nucleic Acids Res. 18:4619-4619(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI."J. Biol. Chem. 268:2571-2576(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents."Gene 248:109-116(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of the selenocysteine to cysteine mutant of human glutathione peroxidase 2 (GPX2)."Submitted (FEB-2009) to the PDB data bank