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Histidyl tRNA Synthetase (HARS)

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HRS; Jo1; HisRS; Histidine tRNA Ligase 1,Cytoplasmic; Autoantigen Jo-1

Histidyl tRNA Synthetase (HARS)
CCC C999
HGNC 4816
MGI 108087
PubMed 10430027
RGD 1310695
UniProt P12081
Wiki HARS

Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases.

The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter.TISSUE SPECIFICITY: Brain, heart, liver and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC999Hu01 Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC999Hu01 Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Histidyl tRNA Synthetase (HARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histidyl tRNA Synthetase (HARS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histidyl tRNA Synthetase (HARS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histidyl tRNA Synthetase (HARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histidyl tRNA Synthetase (HARS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Histidyl tRNA Synthetase (HARS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Histidyl tRNA Synthetase (HARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Histidyl tRNA Synthetase (HARS) ELISA Kit Customized Service Offer
  1. "Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases."Nucleic Acids Res. 20:1075-1081(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase."Nucleic Acids Res. 15:3349-3367(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element."Gene 131:201-208(1993) [PubMed] [Europe PMC] [Abstract]
  7. "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS."Biochem. Biophys. Res. Commun. 210:556-566(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "A loss-of-function variant in the human histidyl-tRNA synthetase (HARS) gene is neurotoxic in vivo."Hum. Mutat. 34:191-199(2013) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase."Submitted (NOV-2005) to the PDB data bank
  13. "Genetic mapping and exome sequencing identify variants associated with five novel diseases." PLoS ONE 7:E28936-E28936(2012) [PubMed] [Europe PMC] [Abstract]