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Methionyl tRNA Synthetase (MARS)

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METRS; MTRNS; MetRS; Methionine tRNA Ligase 1,Cytoplasmic

Methionyl tRNA Synthetase (MARS)
CCC D005
HGNC 6898
MGI 1345633
PubMed 11732605
UniProt P56192
Wiki MARS
Methionyl-tRNA synthetase, cytoplasmic is an enzyme .Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class I family of tRNA synthetases.
Lage and Dietel (1996) isolated a human methionyl-tRNA synthetase cDNA from a gastric carcinoma cell line. The nucleotide sequence predicts a 900-amino acid protein with a molecular mass of 101 kD. The human gene is homologous (33.4% overall identity) to the yeast methionyl-tRNA synthetase gene.Methioninyl-tRNA synthetase has been mapped to chromosome 12 by study of somatic cell hybrids between human peripheral leukocytes and a temperature-sensitive Chinese hamster ovary line with an altered MTRNS.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD005Hu01 Recombinant Methionyl tRNA Synthetase (MARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD005Hu01 Polyclonal Antibody to Methionyl tRNA Synthetase (MARS) WB,IHC
Assay Kits n/a CLIA Kit for Methionyl tRNA Synthetase (MARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionyl tRNA Synthetase (MARS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD005Mu01 Recombinant Methionyl tRNA Synthetase (MARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD005Mu01 Polyclonal Antibody to Methionyl tRNA Synthetase (MARS) WB,IHC,ICC/IF
Assay Kits n/a CLIA Kit for Methionyl tRNA Synthetase (MARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionyl tRNA Synthetase (MARS) ELISA Kit Customized Service Offer
  1. "Cloning of a human cDNA encoding a protein with high homology to yeast methionyl-tRNA synthetase."Gene 178:187-189(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structures of the WHEP-TRS domain of human methionyl-tRNA synthetase."Submitted (OCT-2006) to the PDB data bank
  13. "Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype."BMC Med. Genet. 14:106-106(2013) [PubMed] [Europe PMC] [Abstract]