Glutamyl Prolyl tRNA Synthetase (EPRS)
[Edit]PARS; EARS; PIG32; QPRS; QARS; Bifunctional Aminoacyl-TRNA Synthetase; Glutamate tRNA Ligase; Proline tRNA Ligase; Cell proliferation-inducing gene 32 protein
Alternative splicing has been observed for Glutamyl-PARS), but the full-length nature and biological validity of the variant have not been determined.
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species.Phosphorylation of EPRS is reported to be essential for the formation of GAIT (Gamma-interferon Activated Inhibitor of Translation) complex that regulates the translation of multiple genes in monocytes and macrophages.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD008Hu01 | Recombinant Glutamyl Prolyl tRNA Synthetase (EPRS) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD008Hu01 | Polyclonal Antibody to Glutamyl Prolyl tRNA Synthetase (EPRS) | WB; IHC; ICC; IP. |
Assay Kits | SED008Hu | ELISA Kit for Glutamyl Prolyl tRNA Synthetase (EPRS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPD008Mu01 | Recombinant Glutamyl Prolyl tRNA Synthetase (EPRS) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAD008Mu01 | Polyclonal Antibody to Glutamyl Prolyl tRNA Synthetase (EPRS) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Glutamyl Prolyl tRNA Synthetase (EPRS) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Glutamyl Prolyl tRNA Synthetase (EPRS) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Glutamyl Prolyl tRNA Synthetase (EPRS) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Glutamyl Prolyl tRNA Synthetase (EPRS) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Glutamyl Prolyl tRNA Synthetase (EPRS) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Glutamyl Prolyl tRNA Synthetase (EPRS) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Glutamyl Prolyl tRNA Synthetase (EPRS) | ELISA Kit Customized Service Offer |
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The primary structure of human glutaminyl-tRNA synthetase. A highly conserved core, amino acid repeat regions, and homologies with translation elongation factors."J. Biol. Chem. 266:1448-1455(1991) [PubMed] [Europe PMC] [Abstract]
- "The core region of human glutaminyl-tRNA synthetase homologies with the Escherichia coli and yeast enzymes."Nucleic Acids Res. 16:5391-5406(1988) [PubMed] [Europe PMC] [Abstract]
- "A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase."EMBO J. 10:4267-4277(1991) [PubMed] [Europe PMC] [Abstract]
- "Exons encoding the highly conserved part of human glutaminyl-tRNA synthetase."J. Mol. Evol. 34:45-53(1992) [PubMed] [Europe PMC] [Abstract]
- "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation."Cell 119:195-208(2004) [PubMed] [Europe PMC] [Abstract]
- "A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis."Cancer Res. 65:5638-5646(2005) [PubMed] [Europe PMC] [Abstract]
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
- "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
- "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity."Mol. Cell 35:164-180(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "The first identification of lysine malonylation substrates and its regulatory enzyme."Mol. Cell. Proteomics 10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]
- "Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control."Proc. Natl. Acad. Sci. U.S.A. 108:1415-1420(2011) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
- "Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages."Mol. Cell. Biol. 32:5046-5055(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats."Biochemistry 39:15775-15782(2000) [PubMed] [Europe PMC] [Abstract]