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Alanyl tRNA Synthetase (AARS)

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ATS; PL12; AlaRS; Cytoplasmic; Alanine-TRNA Ligase; Renal Carcinoma Antigen NY-REN-42; Alanine Translase; Alanyl-Transfer Ribonucleate Synthase

Alanyl tRNA Synthetase (AARS)
CCC D010
HGNC 20
MGI 2384560
PubMed 15053876
RGD 1304832
UniProt P49588
Wiki AARS
The AARS gene encodes alanyl-tRNA synthetase. Each of the amino acid synthetases catalyzes the attachment of their respective amino acids to the appropriate tRNA. The class II Escherichia coli and human alanyl-tRNA synthetases cross-acylate their respective tRNAs and require, for aminoacylation, an acceptor helix G3:U70 basepair that is conserved in evolution. The N-terminal 498 amino acids of the 968-residue polypeptide showed 41% identity with the E. coli protein. The human protein contains the class-defining domain of the E. coli enzyme, which includes the part needed for recognition of the acceptor helix G3:U70 basepair as an RNA signal for alanine. The authors concluded that mutagenesis, modeling, domain organization, and biochemical characterization of the E. coli protein are valid as a template for the human protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alanyl tRNA Synthetase (AARS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alanyl tRNA Synthetase (AARS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alanyl tRNA Synthetase (AARS) Polyclonal Antibody Customized Service Offer
Assay Kits SED010Hu ELISA Kit for Alanyl tRNA Synthetase (AARS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alanyl tRNA Synthetase (AARS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alanyl tRNA Synthetase (AARS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alanyl tRNA Synthetase (AARS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alanyl tRNA Synthetase (AARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alanyl tRNA Synthetase (AARS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alanyl tRNA Synthetase (AARS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alanyl tRNA Synthetase (AARS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alanyl tRNA Synthetase (AARS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alanyl tRNA Synthetase (AARS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alanyl tRNA Synthetase (AARS) ELISA Kit Customized Service Offer
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  5. , Submitted (JUL-2007) to UniProtKB
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  10. "The C-Ala domain brings together editing and aminoacylation functions on one tRNA."Science 325:744-747(2009) [PubMed] [Europe PMC] [Abstract]
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  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "A major determinant for binding and aminoacylation of tRNA(Ala) in cytoplasmic Alanyl-tRNA synthetase is mutated in dominant axonal Charcot-Marie-Tooth disease."Am. J. Hum. Genet. 86:77-82(2010) [PubMed] [Europe PMC] [Abstract]
  18. "The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan."PLoS ONE 6:E29393-E29393(2011) [PubMed] [Europe PMC] [Abstract]
  19. "A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with Charcot-Marie-Tooth disease type 2N (CMT2N)."Hum. Mutat. 33:244-253(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges."J. Neurol. 261:970-982(2014) [PubMed] [Europe PMC] [Abstract]