≡

Ryanodine Receptor 2, Cardiac (RYR2)

[Edit]

RYR-2; ARVD2; ARVC2; VTSIP; Arrhythmogenic Right Ventricular Dysplasia 2; Cardiac muscle ryanodine receptor-calcium release channel

Ryanodine Receptor 2, Cardiac (RYR2)
CCC D024
HGNC 10484
MGI 99685
PubMed 11157710
UniProt Q92736
Wiki RYR2

  • Ryanodine receptors (RyRs) form a class of intracellular calcium channels in various forms of excitable animal tissue like muscles and neurons. It is the major cellular mediator of calcium-induced calcium release (CICR) in animal cells.

  • Ryanodine receptor 2 is a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with catecholaminergic polymorphic ventricular tachycardia, stress-induced polymorphic ventricular tachycardia, and arrhythmogenic right ventricular dysplasia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD024Hu01 Recombinant Ryanodine Receptor 2, Cardiac (RYR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD024Hu02 Recombinant Ryanodine Receptor 2, Cardiac (RYR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD024Hu03 Recombinant Ryanodine Receptor 2, Cardiac (RYR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD024Hu01 Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) WB; IHC; ICC; IP.
MAD024Hu21 Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) WB; IHC; ICC; IP.
Assay Kits SED024Hu ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ryanodine Receptor 2, Cardiac (RYR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) Polyclonal Antibody Customized Service Offer
Assay Kits SED024Mu ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD024Ra01 Recombinant Ryanodine Receptor 2, Cardiac (RYR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ryanodine Receptor 2, Cardiac (RYR2) Polyclonal Antibody Customized Service Offer
Assay Kits SED024Ra ELISA Kit for Ryanodine Receptor 2, Cardiac (RYR2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis."Biochem. J. 318:477-487(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)."Hum. Mol. Genet. 10:189-194(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium."Biochem. J. 322:777-783(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum."Neuroscience 85:205-216(1998) [PubMed] [Europe PMC] [Abstract]
  6. "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts."Cell 101:365-376(2000) [PubMed] [Europe PMC] [Abstract]
  7. "S100A1 and calmodulin compete for the same binding site on ryanodine receptor."J. Biol. Chem. 283:26676-26683(2008) [PubMed] [Europe PMC] [Abstract]
  8. "CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation."Circ. Res. 106:1134-1144(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Cardiac excitation-contraction coupling."Nature 415:198-205(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right."Front. Biosci. 14:5134-5156(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Modulation of ryanodine receptor Ca2+ channels."Mol. Med. Report. 3:199-204(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Ryanodine receptors: structure, expression, molecular details, and function in calcium release."Cold Spring Harb. Perspect. Biol. 2:E3996-E3996(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia."Circulation 103:196-200(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia."Circulation 103:485-490(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia."Circulation 106:69-74(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Screening for ryanodine receptor type 2 mutations in families with effort-induced polymorphic ventricular arrhythmias and sudden death: early diagnosis of asymptomatic carriers."J. Am. Coll. Cardiol. 40:341-349(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Molecular genetics of exercise-induced polymorphic ventricular tachycardia: identification of three novel cardiac ryanodine receptor mutations and two common calsequestrin 2 amino-acid polymorphisms."Eur. J. Hum. Genet. 11:888-891(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes."Circulation 110:2119-2124(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Gene symbol: RYR2. Disease: effort-induced polymorphic ventricular arrhythmias."Hum. Genet. 114:404-404(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Gene symbol: RYR2. Disease: effort-induced polymorphic ventricular arrhythmias."Hum. Genet. 114:405-405(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner's cases."Mayo Clin. Proc. 79:1380-1384(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Loss of luminal Ca(2+) activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death."Proc. Natl. Acad. Sci. U.S.A. 104:18309-18314(2007) [PubMed] [Europe PMC] [Abstract]