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Syntaxin 1A, Brain (STX1A)

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STX-1A; HPC-1; STX1; P35-1; Neuron-specific antigen HPC-1

Syntaxin 1A, Brain (STX1A)
CCC D035
HGNC 11433
MGI 109355
PubMed 21910766
RGD 69430
UniProt Q16623
Wiki STX1A
Syntaxin-1A is a protein encoded by the STX1A gene.Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone.
Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis .Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD035Hu01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
APD035Hu01 Active Syntaxin 1A, Brain (STX1A) Cell culture; Activity Assays.
Antibodies PAD035Hu01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
MAD035Hu21 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
Assay Kits SED035Hu ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD035Mu01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
RPD035Mu02 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD035Mu01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAD035Mu02 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
Assay Kits SED035Mu ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Syntaxin 1A, Brain (STX1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Syntaxin 1A, Brain (STX1A) ELISA Kit Customized Service Offer
  1. "Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis."Gene 159:293-294(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome."Am. J. Hum. Genet. 61:449-452(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Refinement of the genomic structure of STX1A and mutation analysis in nondeletion Williams syndrome patients."Am. J. Med. Genet. 109:121-124(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Novel isoform of syntaxin 1 is expressed in mammalian cells."Biochem. J. 321:151-156(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2."Genomics 42:173-176(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, is enhanced by phorbol-ester stimulation in astroglioma: participation of the PKC signaling pathway."FEBS Lett. 536:209-214(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Expression analysis of the human HPC-1/syntaxin 1A, a gene deleted in Williams syndrome."Genomics 62:525-528(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion."Blood 100:1081-1083(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18."J. Biol. Chem. 278:26265-26274(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons."Nat. Cell Biol. 6:941-953(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphoproteomic analysis of synaptosomes from human cerebral cortex."J. Proteome Res. 4:306-315(2005) [PubMed] [Europe PMC] [Abstract]