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Immunoglobulin Kappa (Igk)

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IGKC; HCAK1; Km; Immunoglobulin Kappa Constant; IgA Kappa

Immunoglobulin Kappa (Igk)
CCC D038
HGNC 5716
MGI 96495
PubMed 8458340
UniProt P01834
Wiki IGKC
Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes a the constant domain of kappa-type light chains for antibodies. It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@.The EU sequence has the INV (3) allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV (1,2) allotypic marker, Ala-45 and Leu-83.
Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins).In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region. These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPD038Hu21 OVA Conjugated Immunoglobulin Kappa (Igk) Immunogen; SDS-PAGE; WB.
Antibodies PAD038Hu01 Polyclonal Antibody to Immunoglobulin Kappa (Igk) WB; IHC; ICC; IP.
PAD038Hu08 Polyclonal Antibody to Immunoglobulin Kappa (Igk) WB; IHC; ICC; IP.
Assay Kits SED038Hu ELISA Kit for Immunoglobulin Kappa (Igk) Enzyme-linked immunosorbent assay for Antigen Detection.
CED038Hu ELISA Kit for Immunoglobulin Kappa (Igk) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPD038Mu21 OVA Conjugated Immunoglobulin Kappa (Igk) Immunogen; SDS-PAGE; WB.
EPD038Mu61 Eukaryotic Immunoglobulin Kappa (Igk) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD038Mu01 Polyclonal Antibody to Immunoglobulin Kappa (Igk) WB; IHC; ICC; IP.
PAD038Mu08 Polyclonal Antibody to Immunoglobulin Kappa (Igk) WB; IHC; ICC; IP.
LAD038Mu31 APC/Cy7-Linked Polyclonal Antibody to Immunoglobulin Kappa (Igk) WB; IHC; ICC; IF.
LAD038Mu41 PE-Linked Polyclonal Antibody to Immunoglobulin Kappa (Igk) WB; IHC; ICC; IF.
LAD038Mu51 APC-Linked Polyclonal Antibody to Immunoglobulin Kappa (Igk) WB; IHC; ICC; IF.
Assay Kits SED038Mu ELISA Kit for Immunoglobulin Kappa (Igk) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds."Biochemistry 9:3188-3196(1970) [PubMed] [Europe PMC] [Abstract]
  3. "Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production."Hoppe-Seyler's Z. Physiol. Chem. 353:189-208(1972) [PubMed] [Europe PMC] [Abstract]
  4. "Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments."Cell 22:197-207(1980) [PubMed] [Europe PMC] [Abstract]
  5. , (In) Franek F., Shugar D. (eds.);Gamma globulins: structure and function, pp.57-74, Academic Press, New York (1969)
  6. "The complete amino acid sequence of Bence Jones protein Cum (kappa-type)."Hoppe-Seyler's Z. Physiol. Chem. 348:1718-1722(1967) [PubMed] [Europe PMC] [Abstract]
  7. "The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges."J. Biol. Chem. 244:3550-3560(1969) [PubMed] [Europe PMC] [Abstract]
  8. "Macroglobulin structure: variable sequence of light and heavy chains."Science 169:56-59(1970) [PubMed] [Europe PMC] [Abstract]
  9. "Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain."Biochem. Biophys. Res. Commun. 245:713-716(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular defects in a human immunoglobulin kappa chain deficiency."Science 230:458-461(1985) [PubMed] [Europe PMC] [Abstract]