≡

Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4)

[Edit]

CaMK-GR; Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV; CAM Kinase IV; CAM Kinase-GR

Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4)
CCC D040
HGNC 1464
MGI 88258
PubMed 23130158
RGD 2264
UniProt Q16566
Wiki CAMK4
Calcium/calmodulin-dependent protein kinase type IV is an enzyme belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. Expressed in epithelial ovarian cancer tissue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase IV (CAMK4) ELISA Kit Customized Service Offer
  1. "cDNA cloning and expression of human calmodulin-dependent protein kinase IV."J. Biochem. 115:637-640(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus."Gene 142:191-197(1994) [PubMed] [Europe PMC] [Abstract]
  3. "A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1."J. Virol. 68:1697-1705(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling."J. Biol. Chem. 268:20055-20063(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase."J. Biol. Chem. 269:28640-28647(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression."Mol. Cell. Biol. 14:6107-6116(1994) [PubMed] [Europe PMC] [Abstract]
  8. "CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression."Cell 87:1203-1214(1996) [PubMed] [Europe PMC] [Abstract]
  9. "A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR."J. Biol. Chem. 271:21542-21548(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade."Proc. Natl. Acad. Sci. U.S.A. 93:10803-10808(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18."Mol. Cell. Biol. 17:3459-3467(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Ca(2+)-dependent gene expression mediated by MEF2 transcription factors."J. Biol. Chem. 275:197-209(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer."Cancer Lett. 183:185-193(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex."J. Biol. Chem. 279:31708-31716(2004) [PubMed] [Europe PMC] [Abstract]
  15. "The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription."J. Biol. Chem. 280:20530-20538(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells."Blood 111:723-731(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging."J. Neurosci. 28:9910-9919(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification."J. Biol. Chem. 284:21327-21337(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Calmodulin-dependent protein kinase IV: regulation of function and expression."Biochim. Biophys. Acta 1448:183-189(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Calmodulin-kinases: modulators of neuronal development and plasticity."Neuron 59:914-931(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller."Trends Immunol. 29:600-607(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Crystal structure of human CAMK4 in complex with 4-amino(sulfamoyl-phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)."Submitted (NOV-2008) to the PDB data bank
  27. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]