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Opioid Receptor Mu 1 (OPRm1)

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OPRM; MOR; Mu opiate receptor

Opioid Receptor Mu 1 (OPRm1)
CCC D044
HGNC 8156
MGI 97441
PubMed 18250251
RGD 3234
UniProt P35372
Wiki OPRM1
The μ opioid receptors (MOR) are a class of opioid receptors with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. They are also referred to as μ opioid peptide (MOP) receptors. The prototypical μ receptor agonist is the opium alkaloid morphine; μ (mu) refers to morphine.
There are three well-characterized variants of the μ opioid receptor, though reverse-transcriptase PCR has identified up to 10 total splice variants in humans.More is known about the μ1 opioid receptor than is known about the other types, but some information does exist. TRIMU 5 is a selective agonist of the μ2 receptor.In 2003, a μ3 variant was described, which was responsive to opiate alkaloids but not opioid peptides.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Opioid Receptor Mu 1 (OPRm1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Opioid Receptor Mu 1 (OPRm1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Opioid Receptor Mu 1 (OPRm1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Opioid Receptor Mu 1 (OPRm1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Opioid Receptor Mu 1 (OPRm1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Opioid Receptor Mu 1 (OPRm1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Opioid Receptor Mu 1 (OPRm1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Opioid Receptor Mu 1 (OPRm1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Opioid Receptor Mu 1 (OPRm1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Opioid Receptor Mu 1 (OPRm1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Opioid Receptor Mu 1 (OPRm1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Opioid Receptor Mu 1 (OPRm1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Opioid Receptor Mu 1 (OPRm1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Opioid Receptor Mu 1 (OPRm1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Opioid Receptor Mu 1 (OPRm1) ELISA Kit Customized Service Offer
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  18. "Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell."J. Neurochem. 75:763-771(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells."Exp. Cell Res. 280:192-200(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Agonists activate Gi1 alpha or Gi2 alpha fused to the human mu opioid receptor differently."J. Neurochem. 81:1372-1382(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Selective interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation."J. Biol. Chem. 278:33400-33407(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking."Mol. Pharmacol. 64:1092-1100(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer."Mol. Pharmacol. 67:2173-2184(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Functional complementation and the analysis of opioid receptor homodimerization."Mol. Pharmacol. 68:905-915(2005) [PubMed] [Europe PMC] [Abstract]
  25. "The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor."Biochem. Biophys. Res. Commun. 343:1132-1140(2006) [PubMed] [Europe PMC] [Abstract]
  26. "A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor."Brain Res. 1081:28-33(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity."J. Biol. Chem. 282:8332-8342(2007) [PubMed] [Europe PMC] [Abstract]
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  30. "Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence."BMC Neurosci. 11:33-33(2010) [PubMed] [Europe PMC] [Abstract]
  31. "A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism."Mol. Pain 6:33-33(2010) [PubMed] [Europe PMC] [Abstract]
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  33. "Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction."Proc. Natl. Acad. Sci. U.S.A. 95:9608-9613(1998) [PubMed] [Europe PMC] [Abstract]