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Natriuretic Peptide Receptor 2 (NPR2)

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AMDM; ANPRB; ANPb; NPRBi; NPR-B; GUCY2B; GUC2B; Guanylate Cyclase B; Atrial natriuretic peptide receptor type B

Natriuretic Peptide Receptor 2 (NPR2)
CCC D045
HGNC 7944
MGI 97372
PubMed 24001744
RGD 620851
UniProt P20594
Wiki NPR2

NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein linked and furthermore is a "clearance receptor" which acts to internalise and destroy the ligand. ANP activation of the ANP catalytic receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG) which will then induce smooth muscle relaxation. This is particularly important in the vasculature where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause them to relax. This relaxation will decrease total peripheral resistance which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload and will result in the heart having to do less work.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD045Hu01 Recombinant Natriuretic Peptide Receptor 2 (NPR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD045Hu01 Polyclonal Antibody to Natriuretic Peptide Receptor 2 (NPR2) WB; IHC; ICC; IP.
MAD045Hu21 Monoclonal Antibody to Natriuretic Peptide Receptor 2 (NPR2) WB; IHC; ICC; IP.
Assay Kits SED045Hu ELISA Kit for Natriuretic Peptide Receptor 2 (NPR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Natriuretic Peptide Receptor 2 (NPR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Natriuretic Peptide Receptor 2 (NPR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Natriuretic Peptide Receptor 2 (NPR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Natriuretic Peptide Receptor 2 (NPR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Natriuretic Peptide Receptor 2 (NPR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD045Ra01 Recombinant Natriuretic Peptide Receptor 2 (NPR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD045Ra01 Polyclonal Antibody to Natriuretic Peptide Receptor 2 (NPR2) WB; IHC; ICC; IP.
MAD045Ra21 Monoclonal Antibody to Natriuretic Peptide Receptor 2 (NPR2) WB; IHC; ICC; IP.
Assay Kits SED045Ra ELISA Kit for Natriuretic Peptide Receptor 2 (NPR2) Enzyme-linked immunosorbent assay for Antigen Detection.
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