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Discs, Large Homolog 5 (DLG5)

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LP-DLG; P-DLG5; PDLG; Discs large protein P-dlg; Placenta and prostate DLG

Discs, Large Homolog 5 (DLG5)
CCC D069
HGNC 2904
MGI 1918478
PubMed 17765678
RGD 1308753
UniProt Q8TDM6
Wiki DLG5
DLG5 encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD069Hu01 Recombinant Discs, Large Homolog 5 (DLG5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD069Hu01 Polyclonal Antibody to Discs, Large Homolog 5 (DLG5) WB
Assay Kits n/a CLIA Kit for Discs, Large Homolog 5 (DLG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs, Large Homolog 5 (DLG5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD069Mu01 Recombinant Discs, Large Homolog 5 (DLG5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD069Mu01 Polyclonal Antibody to Discs, Large Homolog 5 (DLG5) WB
Assay Kits n/a CLIA Kit for Discs, Large Homolog 5 (DLG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs, Large Homolog 5 (DLG5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Discs, Large Homolog 5 (DLG5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Discs, Large Homolog 5 (DLG5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Discs, Large Homolog 5 (DLG5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Discs, Large Homolog 5 (DLG5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Discs, Large Homolog 5 (DLG5) ELISA Kit Customized Service Offer
  1. "Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55."FEBS Lett. 433:63-67(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The cloning, genomic organization and tissue expression profile of the human DLG5 gene."BMC Genomics 3:6-6(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact."J. Biol. Chem. 278:21709-21714(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of RSGI RUH-006, the third PDZ domain of HDLG5 (KIAA0583) protein [Homo sapiens]."Submitted (JAN-2004) to the PDB data bank
  11. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]