≡

Carbonic Anhydrase IV (CA4)

[Edit]

CA-IV; CAIV; Car4; RP17; Retinitis Pigmentosa 17(Autosomal Dominant); Carbonate dehydratase IV

Carbonic Anhydrase IV (CA4)
CCC D071
HGNC 1375
MGI 1096574
PubMed 8675662
RGD 2242
UniProt P22748
Wiki CA4
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization.
CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD071Hu01 Recombinant Carbonic Anhydrase IV (CA4) Positive Control; Immunogen; SDS-PAGE; WB.
APD071Hu01 Active Carbonic Anhydrase IV (CA4) Cell culture; Activity Assays.
Antibodies PAD071Hu01 Polyclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IP.
LAD071Hu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC.
LAD071Hu81 FITC-Linked Polyclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IF.
MAD071Hu21 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC/IF
MAD071Hu22 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB
MAD071Hu23 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IP.
MAD071Hu25 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IP.
Assay Kits SED071Hu ELISA Kit for Carbonic Anhydrase IV (CA4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD071Mu01 Recombinant Carbonic Anhydrase IV (CA4) Positive Control; Immunogen; SDS-PAGE; WB.
APD071Mu01 Active Carbonic Anhydrase IV (CA4) Cell culture; Activity Assays.
Antibodies PAD071Mu01 Polyclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Carbonic Anhydrase IV (CA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase IV (CA4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD071Ra01 Recombinant Carbonic Anhydrase IV (CA4) Positive Control; Immunogen; SDS-PAGE; WB.
APD071Ra01 Active Carbonic Anhydrase IV (CA4) Cell culture; Activity Assays.
Antibodies PAD071Ra01 Polyclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC/IF
MAD071Ra21 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB
MAD071Ra24 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IP.
MAD071Ra22 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IP.
MAD071Ra23 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB
MAD071Ra25 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IP.
MAD071Ra26 Monoclonal Antibody to Carbonic Anhydrase IV (CA4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Carbonic Anhydrase IV (CA4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase IV (CA4) ELISA Kit Customized Service Offer
  1. "Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes."Proc. Natl. Acad. Sci. U.S.A. 89:1315-1319(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q."Genomics 16:678-684(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney."J. Biol. Chem. 265:8795-8801(1990) [PubMed] [Europe PMC] [Abstract]
  7. "Carbonic anhydrase IV: purification of a secretory form of the recombinant human enzyme and identification of the positions and importance of its disulfide bonds."Arch. Biochem. Biophys. 333:432-438(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity."Arch. Biochem. Biophys. 320:315-322(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme."Chemistry 12:7057-7066(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design."J. Med. Chem. 49:3019-3027(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."Angew. Chem. Int. Ed. Engl. 46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV."Bioorg. Med. Chem. Lett. 17:628-635(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."Bioorg. Med. Chem. Lett. 17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
  14. "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."Bioorg. Med. Chem. Lett. 19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."J. Am. Chem. Soc. 131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."Proteins 74:164-175(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution."Proc. Natl. Acad. Sci. U.S.A. 93:13589-13594(1996) [PubMed] [Europe PMC] [Abstract]
  18. "Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation."Bioorg. Med. Chem. 18:3307-3319(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration."Hum. Mol. Genet. 14:255-265(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa."Invest. Ophthalmol. Vis. Sci. 48:3459-3468(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Screening for the carbonic anhydrase IV gene mutations in Chinese retinitis pigmentosa patients."Curr. Eye Res. 35:440-444(2010) [PubMed] [Europe PMC] [Abstract]