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Carbonic Anhydrase VB, Mitochondrial (CA5B)

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CA-VB; CAVB; Carbonate dehydratase VB

Carbonic Anhydrase VB, Mitochondrial (CA5B)
CCC D072
HGNC 1378
MGI 1926249
PubMed 10677517
UniProt Q9Y2D0
Wiki CA5B
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization.
CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD072Hu01 Recombinant Carbonic Anhydrase VB, Mitochondrial (CA5B) Positive Control; Immunogen; SDS-PAGE; WB.
APD072Hu01 Active Carbonic Anhydrase VB, Mitochondrial (CA5B) Cell culture; Activity Assays.
Antibodies PAD072Hu01 Polyclonal Antibody to Carbonic Anhydrase VB, Mitochondrial (CA5B) WB; IHC; ICC; IP.
LAD072Hu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase VB, Mitochondrial (CA5B) WB; IHC; ICC.
LAD072Hu81 FITC-Linked Polyclonal Antibody to Carbonic Anhydrase VB, Mitochondrial (CA5B) WB; IHC; ICC; IF.
MAD072Hu21 Monoclonal Antibody to Carbonic Anhydrase VB, Mitochondrial (CA5B) WB; IHC; ICC; IP.
Assay Kits SED072Hu ELISA Kit for Carbonic Anhydrase VB, Mitochondrial (CA5B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD072Mu01 Recombinant Carbonic Anhydrase VB, Mitochondrial (CA5B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD072Mu01 Polyclonal Antibody to Carbonic Anhydrase VB, Mitochondrial (CA5B) WB; IHC; ICC; IP.
LAD072Mu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase VB, Mitochondrial (CA5B) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Carbonic Anhydrase VB, Mitochondrial (CA5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase VB, Mitochondrial (CA5B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD072Ra01 Recombinant Carbonic Anhydrase VB, Mitochondrial (CA5B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD072Ra01 Polyclonal Antibody to Carbonic Anhydrase VB, Mitochondrial (CA5B) WB; IHC; ICC; IP.
LAD072Ra71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase VB, Mitochondrial (CA5B) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Carbonic Anhydrase VB, Mitochondrial (CA5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase VB, Mitochondrial (CA5B) ELISA Kit Customized Service Offer
  1. "Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X."J. Biol. Chem. 274:21228-21233(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."Angew. Chem. Int. Ed. Engl. 46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."Bioorg. Med. Chem. Lett. 17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."Bioorg. Med. Chem. Lett. 19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."J. Am. Chem. Soc. 131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]