Carbonic Anhydrase VIII (CA8)
[Edit]CAVIII; CA-VIII; CALS; CARP; Carbonic anhydrase-related protein
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Carbonic anhydrase-related protein 8 encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family.
The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.The deduced 291-residue gene product was referred to as CA-related protein, or polypeptide (CARP).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD075Hu01 | Recombinant Carbonic Anhydrase VIII (CA8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APD075Hu01 | Active Carbonic Anhydrase VIII (CA8) | Cell culture; Activity Assays. | |
| Antibodies | PAD075Hu01 | Polyclonal Antibody to Carbonic Anhydrase VIII (CA8) | WB; IHC; ICC; IP. |
| Assay Kits | SED075Hu | ELISA Kit for Carbonic Anhydrase VIII (CA8) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Carbonic Anhydrase VIII (CA8) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Carbonic Anhydrase VIII (CA8) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Carbonic Anhydrase VIII (CA8) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Carbonic Anhydrase VIII (CA8) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Carbonic Anhydrase VIII (CA8) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Carbonic Anhydrase VIII (CA8) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Carbonic Anhydrase VIII (CA8) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Carbonic Anhydrase VIII (CA8) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Carbonic Anhydrase VIII (CA8) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Carbonic Anhydrase VIII (CA8) | ELISA Kit Customized Service Offer |
- "The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue."Gene 126:291-292(1993) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing."Proteins 76:507-511(2009) [PubMed] [Europe PMC] [Abstract]
- "CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait."PLoS Genet. 5:E1000487-E1000487(2009) [PubMed] [Europe PMC] [Abstract]