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Carbonic Anhydrase XIV (CA14)

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CA-XIV; CAXIV; Carbonate dehydratase XIV

Carbonic Anhydrase XIV (CA14)
CCC D080
HGNC 1372
MGI 1344341
PubMed 10512682
UniProt Q9ULX7
Wiki CA14
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization.
CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.In melanocytic cells CA14 gene expression may be regulated by MITF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbonic Anhydrase XIV (CA14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbonic Anhydrase XIV (CA14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbonic Anhydrase XIV (CA14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbonic Anhydrase XIV (CA14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase XIV (CA14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbonic Anhydrase XIV (CA14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbonic Anhydrase XIV (CA14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbonic Anhydrase XIV (CA14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbonic Anhydrase XIV (CA14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase XIV (CA14) ELISA Kit Customized Service Offer
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  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme."Chemistry 12:7057-7066(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design."J. Med. Chem. 49:3019-3027(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."Angew. Chem. Int. Ed. Engl. 46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV."Bioorg. Med. Chem. Lett. 17:628-635(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."Bioorg. Med. Chem. Lett. 17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."Bioorg. Med. Chem. Lett. 19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."J. Am. Chem. Soc. 131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."Proteins 74:164-175(2009) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors."Biopolymers 101:769-778(2014) [PubMed] [Europe PMC] [Abstract]