≡

Arachidonate Lipoxygenase 3 (ALOXE3)

[Edit]

ALOX-E3; LOX3; eLOX3; E-LOX; Epidermis-Type Lipoxygenase 3; Hydroperoxy icosatetraenoate dehydratase; Hydroperoxide isomerase ALOXE3

Arachidonate Lipoxygenase 3 (ALOXE3)
CCC D085
HGNC 13743
MGI 1345140
PubMed 22832496
RGD 1306252
UniProt Q9BYJ1
Wiki ALOXE3
LOX-3is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE).
This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD085Hu01 Recombinant Arachidonate Lipoxygenase 3 (ALOXE3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD085Hu01 Polyclonal Antibody to Arachidonate Lipoxygenase 3 (ALOXE3) WB; IHC; ICC; IP.
MAD085Hu21 Monoclonal Antibody to Arachidonate Lipoxygenase 3 (ALOXE3) WB; IHC; ICC; IP.
Assay Kits SED085Hu ELISA Kit for Arachidonate Lipoxygenase 3 (ALOXE3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arachidonate Lipoxygenase 3 (ALOXE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arachidonate Lipoxygenase 3 (ALOXE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arachidonate Lipoxygenase 3 (ALOXE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arachidonate Lipoxygenase 3 (ALOXE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arachidonate Lipoxygenase 3 (ALOXE3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Arachidonate Lipoxygenase 3 (ALOXE3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Arachidonate Lipoxygenase 3 (ALOXE3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Arachidonate Lipoxygenase 3 (ALOXE3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Arachidonate Lipoxygenase 3 (ALOXE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Arachidonate Lipoxygenase 3 (ALOXE3) ELISA Kit Customized Service Offer
  1. "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression."Genomics 73:323-330(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase."Proc. Natl. Acad. Sci. U.S.A. 100:9162-9167(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin."Arch. Biochem. Biophys. 455:188-196(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids."J. Biol. Chem. 285:39866-39875(2010) [PubMed] [Europe PMC] [Abstract]
  7. "On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1."J. Biol. Chem. 285:39876-39887(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope."J. Biol. Chem. 286:24046-24056(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1."Hum. Mol. Genet. 11:107-113(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3."Biochim. Biophys. Acta 1686:238-247(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Mutation spectrum and functional analysis of epidermis-type lipoxygenases in patients with autosomal recessive congenital ichthyosis."Hum. Mutat. 26:351-361(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B."J. Invest. Dermatol. 129:1421-1428(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Genotypic and clinical spectrum of self-improving collodion ichthyosis: ALOX12B, ALOXE3, and TGM1 mutations in Scandinavian patients."J. Invest. Dermatol. 130:438-443(2010) [PubMed] [Europe PMC] [Abstract]