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Hemoglobin Zeta (HBz)

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BAZ; HBZ2; Zeta-Globin

Hemoglobin Zeta (HBz)
CCC D091
HGNC 4835
MGI 96019
PubMed 6171809
UniProt P02008
Wiki HBZ
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult like. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'.Its composition was found to be gamma(2) X(2). It was originally thought that the X-chain might be the epsilon chain whose synthesis persisted until after birth because of the chromosomal anomaly; later work indicated that the X-chain is indeed different from epsilon and therefore it is now called zeta. Hb Portland-2 is the designation for zeta(2)-beta(2) found in stillborn infants with homozygous alpha-thalassemia .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hemoglobin Zeta (HBz) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hemoglobin Zeta (HBz) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hemoglobin Zeta (HBz) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hemoglobin Zeta (HBz) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Zeta (HBz) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hemoglobin Zeta (HBz) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hemoglobin Zeta (HBz) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hemoglobin Zeta (HBz) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hemoglobin Zeta (HBz) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Zeta (HBz) ELISA Kit Customized Service Offer
  1. "The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene."Cell 31:553-563(1982) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA."DNA 1:355-363(1982) [PubMed] [Europe PMC] [Abstract]
  3. "The relationship between chromosome structure and function at a human telomeric region."Nat. Genet. 15:252-257(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human embryonic haemoglobins. The primary structure of the zeta chains."Hoppe-Seyler's Z. Physiol. Chem. 362:1159-1162(1981) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of the zeta chain of human embryonic hemoglobin."Proc. Natl. Acad. Sci. U.S.A. 78:6076-6080(1981) [PubMed] [Europe PMC] [Abstract]
  8. "Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains."Hoppe-Seyler's Z. Physiol. Chem. 362:1657-1659(1981) [PubMed] [Europe PMC] [Abstract]
  9. "Human hemoglobin Portland II (zeta 2 beta 2). Isolation and characterization of Portland hemoglobin components and their constituent globin chains."J. Biol. Chem. 259:7325-7330(1984) [PubMed] [Europe PMC] [Abstract]
  10. "Quantities of adult, fetal and embryonic globin chains in the blood of eighteen- to twenty-week-old human fetuses."J. Chromatogr. B 567:359-368(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Haemoglobin level, proportion of haemoglobin Bart's and haemoglobin Portland in fetuses affected by homozygous alpha0-thalassemia from 12 to 40 weeks' gestation."Prenat. Diagn. 30:1126-1130(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "The role of beta chains in the control of the hemoglobin oxygen binding function: chimeric human/mouse proteins, structure, and function."Biochemistry 40:15669-15675(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of fully liganded Hb zeta2beta2s trapped in a tense conformation."Acta Crystallogr. D 69:2061-2071(2013) [PubMed] [Europe PMC] [Abstract]